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Table 4 Comparison of clinical and laboratory parameters between severe and non-severe grading of necroinflammatory activity in liver histology

From: Interleukin-21 plays a critical role in the pathogenesis and severity of type I autoimmune hepatitis

 

Grading of necroinflammatory activity: G0–2 (n = 11)

Grading of necroinflammatory activity: G3–4 (n = 8)

p

ALT (U/l)

420 ± 426

818 ± 1088

0.3484

Alb (g/dl)

3.5 ± 0.8

3.0 ± 0.8

0.0860

TB (mg/dl)

3.2 ± 6.4

11.0 ± 9.6

<0.05*

PT (%)

68.7 ± 28.4

74.1 ± 18.6

0.9150

PLT (×104/μl)

16.5 ± 6.2

13.1 ± 4.2

0.2014

IgG (mg/dl)

2307 ± 1131

2836 ± 548

0.1767

IL-21 (pg/ml)

211.7 ± 135.3

414.9 ± 142.7

<0.01*

IL-18 (pg/ml)

903.8 ± 667.4

1069.2 ± 891.9

0.8910

CCL20 (pg/ml)

55.4 ± 62.5

329.3 ± 302.8

<0.01*

CCR6 (pg/ml)

113.3 ± 112.6

142.5 ± 99.1

0.4381

CXCL9 (pg/ml)

1356.8 ± 1036.9

2020.8 ± 963.6

0.1084

CXCR3 (ng/ml)

51.7 ± 43.6

82.9 ± 41.6

0.1084

  1. AST aspartate aminotransferase, ALT alanine aminotransferase, ALP alkaline phosphatase, IgG immunoglobulin G, IL-21 interleukin 21, IL-18 interleukin 18, CCL20 C–C chemokine ligand 20, CCR6 C–C chemokine receptor 6, CXCL9 CXC chemokine ligand 9, CXCR3 CXC chemokine receptor 3
  2. p values were calculated with the Mann–Whitney U test (*statistically significant)