Table 2 Comparison of clinical and laboratory parameters between severe and non-severe autoimmune hepatitis
From: Interleukin-21 plays a critical role in the pathogenesis and severity of type I autoimmune hepatitis
|  | Non-severe (n = 17) | |||
|---|---|---|---|---|
|  | Mild (n = 4) | Moderate (n = 13) | Severe (n = 5) | p |
ALT (U/l) | 96 ± 66 | 599 ± 858 | 729 ± 590 | 0.2488 |
Alb (g/dl) | 4.0 ± 0.2 | 3.4 ± 0.6 | 2.7 ± 0.8 | <0.05* |
TB (mg/dl) | 0.9 ± 0.3 | 7.5 ± 10.7 | 12.0 ± 8.9 | 0.1138 |
PT (%) | 95.5 ± 2.8 | 77.9 ± 19.4 | 46.4 ± 12.2 | <0.005* |
PLT (×104/μl) | 20.9 ± 5.4 | 14.6 ± 4.4 | 11.5 ± 2.9 | 0.1117 |
IgG (mg/dl) | 2834 ± 725 | 2415 ± 1112 | 2910 ± 1042 | 0.4455 |
IL-21 (pg/ml) | 244.5 ± 146.6 | 270.3 ± 173.4 | 396.7 ± 99.9 | <0.05* |
IL-18 (pg/ml) | 366.2 ± 213.2 | 944.8 ± 846.9 | 1776.6 ± 891.2 | <0.05* |
CCL20 (pg/ml) | 58.4 ± 45.9 | 215.3 ± 316.9 | 255.2 ± 247.7 | 0.2488 |
CCR6 (pg/ml) | 26.2 ± 9.2 | 147.8 ± 133.7 | 163.9 ± 71.2 | 0.1196 |
CXCL9 (pg/ml) | 1206.7 ± 1370.2 | 1419.9 ± 1004.9 | 1953.5 ± 903.1 | 0.2488 |
CXCR3 (ng/ml) | 43.7 ± 61.0 | 54.4 ± 34.7 | 86.8 ± 47.5 | 0.1012 |