Skip to main content
SpringerPlus

Table 1 Characteristic of the study population

From: CXCL13 chemokine as a promising biomarker to diagnose neurosyphilis in HIV-negative patients

Characteristic value

Neurosyphilis (n = 40)

Syphilis/non-neurosyphilis (n = 31)

Non-syphilis

Healthy volunteers (n = 49)

P

Other CNS infection (n = 11)

Non CNS infection (n = 15)

 

n (%)

n (%)

n (%)

n (%)

n (%)

 

Male sex

30 (75.0)

18 (58.1)

6 (54.5)

6 (40)

28 (57.1)

0.158

Serum RPR ≥ 1:32

20 (50.0)

4 (12.9)

0

0

0

 

Reactive CSF RPR

23 (57.5)

0

0

0

0

 
 

P50 (P25–P75)

P50 (P25–P75)

P50 (P25–P75)

P50 (P25–P75)

P50 (P25–P75)

 

Agea (years)

54 (46–58)

49 (39–59)

41 (29–52)

50 (24–70)

34 (28–47)

<0.001 f

CSF WBCb (10 × 106/L)

25 (8–126)

7 (3–14)

53 (7–82) 

5 (2–13)

ND

0.001 f

CSF Protein (500 mg/L)

461.3 (351.2–676.9)

386.6 (323.6–523.9)

853.3 (266.0–1499.1)

478.5 (344.2–587.2)

ND

0.141

albumin quotient

6.0 (4.2–8.9)

5.3 (3.4–7.2)

9.0 (5.2–17.8)

8.8 (3.9–18.1)

ND

0.058

Serum CXCL13c (pg/mL)

140.3 (82.5–200.5)

82.5 (55.0–136.7)

170.2 (158.4–188.7)

118.7 (96.0–188.7)

23.4 (15.0–37.4)

<0.001 f

CSF CXCL13d (pg/mL)f

10.1 (5.2–20.8)

0.4 (0–3.9)

5.4 (1.4–14.8)

0.1 (0–8.8)

ND

<0.001 f

Q eCXCL13

9.3 (4.6–32.0)

0.6 (0–13.0)

3.9 (0.5–8.7)

0.1 (0–4.8)

ND

<0.001 f

  1. Characteristics of the study participants were shown in Table 1. Concentration of CXCL13 in serum , concentration of CXCL13 in CSF  and QCXCL13 were statistical significace and different among neurosyphilis group, syphilis/non-neurosyphilis group, non-syphilis group and healthy volunteers. The serum CXCL13 level was significantly higher in neurosyphilis and in syphilis/non-neurosyphilis as compared to healthy volunteers (x2 = 48.491, P < 0.001; x2 = 17.170, P < 0.001). The CSF concentration of CXCL13 was remarkably increased in patients with neurosyphilis as compared to the other two groups of syphilis/non-neurosyphilis (x2 = 21.802, P < 0.001) and non-syphilis (x2 = 7.677, P = 0.002). The QCXCL13 was higher in neurosyphilis as compared to syphilis/non-neurosyphilis (x2 = 12.352, P = 0.002) and as compared to non-syphilis (x2 = 9.335, P = 0.009). ND not detected
  2. aNeurosyphilis versus healthy volunteers, P < 0.001; syphilis/non-neurosyphilis versus healthy volunteers, P = 0.008
  3. bNeurosyphilis versus syphilis/non-neurosyphilis, P = 0.018; neurosyphilis versus non-syphilis/non CNS infection, P = 0.024; non-syphilis/other CNS infection versus non-syphilis/non CNS infection, P = 0.002
  4. cNeurosyphilis versus healthy volunteers, P < 0.001; syphilis/non-neurosyphilis versus non-syphilis/other CNS infection, P = 0.022; syphilis/non-neurosyphilis versus healthy volunteers, P < 0.001; non-syphilis/other CNS infection versus healthy volunteers, P < 0.001; non-syphilis/non CNS infection versus healthy volunteers, P < 0.001
  5. dNeurosyphilis versus syphilis/non-neurosyphilis, P < 0.001; neurosyphilis versus non-syphilis/non CNS infection, P = 0.009
  6. eNeurosyphilis versus syphilis/non-neurosyphilis, P = 0.001; neurosyphilis versus non-syphilis/non CNS infection, P = 0.003
  7. fData was compared to different groups, the difference was statistically significant
Back to article page