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Table 2 Dose limiting toxicities in patients randomized to mifepristone for cycle 1

From: A randomized phase I trial of nanoparticle albumin-bound paclitaxel with or without mifepristone for advanced breast cancer

Patient

DLT

Type of DLT

Dose level 1: nab-paclitaxel 100 mg/m2 + mifepristone 300 mg

 2-M

Y

Neutropenia

 4-M

Y

Neutropenia

Dose Level −1: nab-paclitaxel 80 mg/m2 + mifepristone 300 mg

 5-M

Y

Neutropenia

 6-M

N

None

 9-M

Y

Neutropenia

  1. Only patients randomized to mifepristone for cycle 1 were used for DLT determination
  2. M denotes patients randomized to mifepristone for cycle 1
  3. Y yes, N no
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