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Table 3 Change in LDH, ROS, MMP and caspase activities at IC50 and IC70 concentrations of CoCl2·6H2O for 12–14 h treatment in PC-3 cancer cell line with respect to untreated PC-3 cells

From: Effect of cobalt(II) chloride hexahydrate on some human cancer cell lines

  LDH ROS MMP Caspase
Untreated PC-3 cells 100 100 100 100
Camptothecin (10 µM) treated PC-3 cells 126.7 176.5 72.7 174.1
CoCl2·6H2O (IC50) treated PC-3 cells 123.2 152.9 80 170.4
CoCl2·6H2O (IC70) treated PC-3 cells 138.2 211.8 73.3 177.8
χ2 27.07*** 211.42*** 18.55*** 164.88***
  1. IC50 and IC70 doses calculated using regression equation: y = 21.86 ln(x) − 17.49
  2. *** P < 0.001; n = 3