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Tableย 3 Change in LDH, ROS, MMP and caspase activities at IC50 and IC70 concentrations of CoCl2ยท6H2O for 12โ€“14ย h treatment in PC-3 cancer cell line with respect to untreated PC-3 cells

From: Effect of cobalt(II) chloride hexahydrate on some human cancer cell lines

ย 

LDH

ROS

MMP

Caspase

Untreated PC-3 cells

100

100

100

100

Camptothecin (10ย ยตM) treated PC-3 cells

126.7

176.5

72.7

174.1

CoCl2ยท6H2O (IC50) treated PC-3 cells

123.2

152.9

80

170.4

CoCl2ยท6H2O (IC70) treated PC-3 cells

138.2

211.8

73.3

177.8

ฯ‡2

27.07***

211.42***

18.55***

164.88***

  1. IC50 and IC70 doses calculated using regression equation: yย =ย 21.86 ln(x)ย โˆ’ย 17.49
  2. ***ย Pย <ย 0.001; nย =ย 3