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Table 2 Percent inhibition, IC50 values of various cell lines treated with different concentrations of CoCl2·6H2O (5–100 mg/L) by using best fit regression model

From: Effect of cobalt(II) chloride hexahydrate on some human cancer cell lines

Concentration of CoCl2·6H2O (mg/L) (x)
Cell line Inhibition (%) (y) Regression equation IC50
5 10 25 50 75 100
293 T 7.27 16.97 27.73 47.26 62.67 69.72 y = 20.92 ln(x) − 31.03
R = 0.977***
48.1
IMR-32 31.24 66.60 77.22 78.10 79.01 79.22 y = 13.59 ln(x) + 23.33
R = 0.849***
7.12
PC-3 19.80 31.58 49.70 67.98 80.36 82.08 y = 21.86 ln(x) − 17.49
R = 0.995***
21.91
A549 0.817 5.48 46.92 73.61 80.02 80.79 y = 30.61 ln(x) − 53.93
R = 0.980***
29.81
Two-way ANOVA summary table
Source of variation df SS MSS F-ratio Tukey’s HSD0.05 4.79
Treatment (cell line) 3 8632.36 2877.45 470.06***   
Dose (CoCl2·6H2O) 5 39,715.85 7943.17 1297.59***   
Treatment × dose (interaction) 15 5669.54 377.97 61.75***   
Error 48 293.83 6.12    
Total 71 54,311.57     
  1. R *** P < 0.001; *** P < 0.001; n = 5