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Table 2 Allele and genotype frequencies of HOMER1 rs2290639 in HC, SA, MDD and non-SA

From: Association of HOMER1 rs2290639 with suicide attempts in Hong Kong Chinese and the potentially functional role of this polymorphism

Model

HC (n = 84)

SA (n = 111)

MDD (n = 160)

Non-SA (n = 189)

SA versus HC

SA versus non-SA

MDD versus HC

P (X 2)

P (logistic)

P (X 2)

P (logistic)

P (Perm)

P (X 2)

P (logistic)

Allelic

A

65 (38.7)

92 (41.4)

122 (38.1)

138 (36.5)

0.585

0.994

0.230

0.195

–

0.903

0.621

T

103 (61.3)

130 (58.6)

198 (61.9)

240 (63.5)

Genotypic

AA

10 (11.9)

22 (19.8)

23 (14.4)

16 (8.5)

0.226

0.833

0.009

0.013

0.008

0.653

0.606

AT

45 (53.6)

48 (43.3)

76 (47.5)

106 (56.1)

TT

29 (34.5)

41 (36.9)

61 (38.1)

67 (35.4)

Homozygous

AA

10 (11.9)

22 (19.8)

23 (14.4)

16 (8.5)

0.326

0.844

0.033

0.032

0.043

0.839

0.823

TT

29 (34.5)

41 (36.9)

61 (38.1)

67 (35.4)

Heterozygous

AT

45 (53.6)

48 (43.3)

76 (47.5)

106 (56.1)

0.377

0.308

0.253

0.262

–

0.455

0.388

TT

29 (34.5)

41 (36.9)

61 (38.1)

67 (45.4)

Recessive

AA

10 (11.9)

22 (19.8)

23 (14.4)

16 (8.5)

0.139

0.354

0.004

0.005

0.005

0.592

0.568

AT + TT

74 (88.1)

89 (80.2)

137 (85.6)

173 (91.5)

  1. HC healthy controls, SA suicide attempt patients, MDD major depressive disorder patients, non-SA non-suicide attempts subjects with psychiatric disorders, OR odds ratio, CI confidence interval. Data is shown in number (%); P(X 2): P value were calculated by Chi square test; P (logistic): P value calculated by logistic regression analysis after controlling by sex and age in SA versus HC and MDD versus HC; P value calculated by logistic regression analysis after controlling by sex, age, MDD, bipolar disorder and schizophrenia in SA versus non-SA; P (Perm): adjusted P value after 2000 permutations tests for the significant results in Chi square tests; P values below 0.05 are in italics