Therapeutic hypothermia versus normothermia in adult patients with traumatic brain injury: a meta-analysis

Zhu, Youfeng; Yin, Haiyan; Zhang, Rui; Ye, Xiaoling; Wei, Jianrui

doi:10.1186/s40064-016-2391-2

SpringerPlus

Table 2 Characteristics and demographic parameters of patients in the included studies

From: Therapeutic hypothermia versus normothermia in adult patients with traumatic brain injury: a meta-analysis

References	N	Age (years)	Gender (M/F)	Target T (°C)	Time from TBI to strating TH (h)	Duration of hypothermia (h)	Duration of rewarming
Clifton et al. (1993)
Hypothermia	24	16–55	Unknown	32–33	6	48	1 °C/4 h
Normothermia	22	16–60	Unknown	32–33	6	48	1 °C/4 h
Shiozaki et al. (1993)
Hypothermia	16	35.3 ± 15.3	6 M, 10 F	34	5–6	>48	>24 h
Normothermia	17	35.4 ± 12.6	10 M, 7 F	34	5–6	>48	>24 h
Marion et al. (1997)
Hypothermia	40	31 ± 12	36 M, 4 F	32–33	Unknown	24	<1 °C/h
Normothermia	42	35 ± 15	33 M, 9 F
Shiozaki et al. (1999)
Hypothermia	8	31.4 ± 12.7	8 M, 0 F	33.5–34.5 (intracranial)	Unknown	48	1 °C/day
Normothermia	8	40.3 ± 23.1	5 M, 3 F	33.5–34.5 (intracranial)	Unknown	48	1 °C/day
Jiang et al. (2000)
Hypothermia	43	42.2	35 M, 8 F	33–35	15	72–366	1 °C/h
Normothermia	44	40.6	37 M, 7 F	33–35	15	72–366	1 °C/h
Clifton et al. (2001)
Hypothermia	199	31 ± 12	Unknown	33	6	48	0.25 °C/h
Normothermia	193	32 ± 13	Unknown	33	6	48	0.25 °C/h
Shiozaki et al. (2001)
Hypothermia	45	35 ± 20	35 M, 10 F	34	Unknown	48	1 °C/24 h
Normothermia	46	32 ± 17	31 M, 15 F
Gal et al. (2002)
Hypothermia	15	Unknown	Unknown	34	15	72	Unknown
Normothermia	15	Unknown	Unknown	34	15	72	Unknown
Hashiguchi et al. (2003)
Hypothermia	9	29 ± 14.9	9 M, 0 F	34 (intracranial)	Unknown	48	1 °C/day
Normothermia	8	39.1 ± 13.2	5 M, 3 F	34 (intracranial)	Unknown	48	1 °C/day
Zhi et al. (2003)
Hypothermia	198	43 ± 17	Unknown	32–35	9	62.4	0.25 °C/h
Normothermia	198	42 ± 19	Unknown	32–35	9	62.4	0.25 °C/h
Qiu et al. (2005)
Hypothermia	43	40	26 M, 17 F	33–35	Unknown	72–120	Unknown
Normothermia	43	42.3	30 M, 13 F	33–35	Unknown	72–120	Unknown
Qiu et al. (2006)
Hypothermia	45	40.1 ± 9.8	29 M, 20 F	33–35	Unknown	72	8–20 h
Normothermia	45	41.8 ± 11.7	30 M, 15 F
Qiu et al. (2007)
Hypothermia	40	41.3	25 M, 15 F	33–35	4.1	96	10–24 h
Normothermia	40	40.2	27 M, 13 F	33–35	4.1	96	10–24 h
Lee et al. (2010)
Hypothermia	29	44.0 ± 15.1	17 M, 12F	33–35	Unknown	Unknown	Unknown
Normothermia	16	43.5 ± 16.4	10 M, 6 F	33–35	Unknown	Unknown	Unknown
Zhao et al. (2011)
Hypothermia	40	36.9 ± 14.8	29 M, 10 F	32.7	Within 24	72	Unknown
Normothermia	41	37.5 ± 15.2	30 M, 11 F	32.7	Within 24	72	Unknown
Clifton et al. (2011)
Hypothermia	52	26	Unknown	33–35	1.6	48	0.5 °C/2 h
Normothermia	45	31	Unknown	33–35	1.6	48	0.5 °C/2 h
Maekawa et al. (2015)
Hypothermia	98	39 ± 19	69 M, 29 F	32–34	Within 2	≥72	1 °C/1 day
Normothermia	50	39 ± 18	34 M, 16 F	32–34	Within 2	≥72	1 °C/1 day
Andrews et al. (2015)
Hypothermia	191	37.4 ± 15.4	Unknown	32–35	Unknown	>48	1 °C/4 h
Normothermia	189	36.7 ± 14.9	Unknown	32–35	Unknown	>48	1 °C/4 h

Plus–minus values are mean ± SD
M male, F female, T temperature, N number, TH therapeutic hypothermia

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