Fig. 2
From: The effect of the immune system on ovarian function and features of ovarian germline stem cells
Modified from Bukovsky and Caudle (2012)
The role of the immune system in promoting the symmetric and asymmetric division and differentiation of ovarian germ stem cells. a Uncommitted OGSCs(u-OGSCs) were produced in the first six weeks of pregnancy; b Primordial germ cells (PGC) were invaded OGSCs layerin the first seven weeks of pregnancy; c–e OGSCs only the joint action of cell signaling (cellular signaling, CS; as CD14 secreted by MDC and CD8 secreted by T lymphocytes) and hormonal signals (hormonal signaling, HS; chorionic gonadotropin, hCG and estradiol, E2) can occur secondary asymmetric division to produce germ cells, germ cells into secondary ovarian cortex and eventually differentiate into oocytes (definitive oocytes, DO).