Fig. 4

Images of an 81-year-old woman with liver cirrhosis and a hepatocellular carcinoma (HCC) in segment 4. A Sonazoid is injected at a rate of 0.5 mL/s. The CEUS image at peak enhancement shows clear hypervascularity; the resulting average visual rating is 4.5 (reader 1: 4, reader 2: 5). A red circular region of interest is placed on the HCC and a blue region of interest is placed in adjacent liver parenchyma. The lesion-to-liver contrast ratio is 4.70. B Sonazoid is injected at a rate of 2.0 mL/s. The CEUS image at peak enhancement shows isovascularity to slight hypervascularity; the resulting average visual rating is 3 (reader 1: 3, reader 2: 3). A red circular region of interest is placed on the HCC and a blue region of interest is placed in adjacent liver parenchyma. The lesion-to-liver contrast ratio is 1.80