Table 5 Comparative analysis of toxicity: original drug versus generic no. 3
From: Toxicities of docetaxel: original drug versus generics—a comparative study about 81 cases
Original drug (n = 38) | Generic no. 3 (n = 11) | p | |
|---|---|---|---|
Hypersensitivity | 1 (2.6 %) | 0 (0 %) | 1 |
Peripheral sensory neuropathy | 2 (5.3 %) | 3 (27.3 %) | 0.06 |
Hematological toxicities | 5 (13.2 %) | 7 (63.6 %) | 0.002 |
Febrile neutropenia | 1 (2.6 %) | 2 (18.2 %) | 0.12 |
Gastrointestinal toxicity | 2 (5.3 %) | 1 (9.1 %) | 0.54 |
Skin toxicity (extra nail hypermelanosis) | 0 (0 %) | 1 (9.1 %) | 0.22 |
Treatment discontinuation | 3 (7.9 %) | 8 (72.7 %) | <0.001 |