Table 2 Comparative analysis of the toxicity of docetaxel: original drug versus generics
From: Toxicities of docetaxel: original drug versus generics—a comparative study about 81 cases
Toxicities | Original drug (n = 38) | Generics (n = 43) | p |
|---|---|---|---|
Hypersensitivity | 1 (2.6 %) | 0 (0 %) | 0.46 |
Peripheral sensory neuropathy | 2 (5.3 %) | 7 (16.3 %) | 0.16 |
Hematological toxicities | 5 (13.2 %) | 14 (32.6 %) | 0.04 |
Febrile neutropenia | 1 (2.6 %) | 4 (9.3 %) | 0.36 |
Gastrointestinal toxicity | 2 (5.3 %) | 6 (14 %) | 0.27 |
Skin toxicity | 0 (0 %) | 5 (11.6 %) | 0.05 |
Extra nail hypermelanosis | 0 (0 %) | 1 (2.3 %) | 1 |
Hand foot syndrome grade III | 0 (0 %) | 3 (7 %) | 0.24 |
Ichthyosis-like eruption | 0 (0 %) | 1 (2.3 %) | 1 |
Treatment discontinuation | 3 (7.9 %) | 17 (39.5 %) | 0.001 |