Insights into the interactions between tetracycline, its degradation products and bovine serum albumin

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Table 2 Binding constants, binding-site numbers and relative thermodynamic parameters of TC and its degradation products with BSA

Drug	Temperature (K)	K_A (L mol⁻¹)	n	R²	∆G (KJ mol⁻¹)	∆H (KJ mol⁻¹)	∆S (J mol⁻¹ K⁻¹)
TC	293	5.13 × 10⁴	1.01	0.996	−26.40	−19.41	23.86
	298	4.50 × 10⁴	1.17	0.997	−26.52
	304	3.60 × 10⁴	1.17	0.999	−26.66
	310	3.39 × 10⁴	1.18	0.999	−26.81
ATC	293	1.87 × 10⁵	1.07	0.999	−29.40	−15.10	48.80
	298	1.45 × 10⁵	1.18	0.998	−29.64
	304	1.36 × 10⁵	1.09	0.998	−29.94
	310	1.30 × 10⁵	1.08	0.999	−30.23
ETC	293	2.95 × 10⁴	1.00	0.998	−24.96	−12.12	43.81
	298	2.44 × 10⁴	1.05	0.999	−25.18
	304	2.30 × 10⁴	1.12	0.999	−25.44
	310	2.21 × 10⁴	1.17	0.995	−25.70