Table 1 Enumeration of differentiating points between keratoglobus, anterior megalophthalmos and buphthalmos
Keratoglobus | Anterior megalophthalmos | Buphthalmos/infantile glaucoma | |
|---|---|---|---|
Inheritance | No definite pattern | X-linked recessive | Sporadic |
Age of presentation | Puberty | Congenital | First year of life |
Natural History | Progressive | Non-progressive | Progressive |
Symptoms | Frequent change of glasses | Variable and nonspecific | Watering, photophobia |
Intra ocular pressure (IOP) | Normal | Normal | Elevated |
Corneal diameter | >13mm; symmetric with increased WTW diameter | >13mm; symmetric | Variable, depends upon severity of glaucoma |
Axial length | Increased axial length | Normal | Increased axial length |
Iris | Iridodonesis ± | Iridodonesis; iris stromal hypoplasia | Normal with high insertion |
Optic disc | Usually normal | Normal with increased propensity for glaucoma | Cup:disc ratio increased |
Treatment | Refractive error correction and keratoplasty in advanced cases | Refractive errors correction | Control of IOP (medically/surgically) |