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Table 2 Antibiotic resistance level of our invasive K. pneumoniae strains and those of 30 European countries

From: Decreasing level of resistance in invasive Klebsiella pneumoniae strains isolated in Marseille, January 2012–July 2015

Country Total number of strains a Number of strains tested and percentage of resistance per antibiotic tested p valueb
AMC TZP CRO IMP CIP GM SXT FT CRO IMP CIP GM
No % No % No % No % No % No % No % No %
Our study 447 127 41.7 349 29.4 440 29.5 446 0.4 445 33.5 440 1 18.2 441 31.5 441 47.2     
Austria 3315      3315 12.0 2767 0.8 3271 16.4 3315 5.8      p < 10−3 0.7 p < 10−3 p < 10−3
Belgium 1978      1945 14.9 1925 0.4 1978 17.7 1844 8.9      p < 10−3 1 p < 10−3 p < 10−3
Bulgaria 513      513 75.1 479 0.4 512 49.0 512 62.5      p < 10−3 1 0.002 p < 10−3
Croatia 1289      1288 51.3 1285 0.6 1274 43.9 1289 47.6      p < 10−3 1 0.01 p < 10−3
Cyprus 283      283 32.9 283 12.0 283 30.4 283 23.0      0.6 p < 10−3 0.6 0.2
Czech Republic 5240      5240 50.0 4736 0.3 5240 51.5 5218 49.3      p < 10−3 0.8 p < 10−3 p < 10−3
Denmark 3473      2346 10.9 2405 0.1 3376 10.1 3473 5.6      p < 10−3 0.4 p < 10−3 p < 10−3
Estonia 338      304 22.4 292 1.0 332 22.6 338 14.5      0.1 0.6 0.01 0.3
Finland 1883      1883 2.5 1877 0.0 1874 2.4 1815 1.6      p < 10−3 0.04 p < 10−3 p < 10−3
France 6845      6845 23.7 6541 0.3 6817 26.1 6287 23.1      0.03 1 0.01 0.07
Germany 2407      2407 13.8 2380 0.2 2405 14.4 2402 9.3      p < 10−3 0.7 p < 10−3 p < 10−3
Greece 6018      6018 73.1 5992 59.2 5911 70.3 5939 63.5      p < 10−3 p < 10−3 p < 10−3 p < 10−3
Hungary 2000      2000 44.3 1916 3.0 1964 42.8 2000 44.2      p < 10−3 0.004 0.02 p < 10−3
Iceland 99      97 6.2 97 0.0 90 2.2 99 0.0      p < 10−3 1 p < 10−3 p < 10−3
Ireland 1277      1264 11.2 1258 0.1 1275 9.7 1277 10.3      p < 10−3 0.6 p < 10−3 p < 10−3
Italy 3702      3621 50.1 3644 28.0 3556 48.8 3702 39.3      p < 10−3 p < 10−3 p < 10−3 p < 10−3
Latvia 299      299 56.9 297 0.0 292 44.9 299 47.5      p < 10−3 0.7 0.05 p < 10−3
Lithuania 549      549 55.9 391 0.0 545 49.7 549 55.6      p < 10−3 0.5 0.001 p < 10−3
Luxembourg 210      210 26.2 206 0.5 210 22.8 210 21.4      0.5 1 0.05 0.5
Malta 235      235 20.4 235 3.4 235 21.3 235 19.2      0.06 0.008 0.01 0.9
Netherlands 2711      2688 7.4 2692 0.2 2680 6.5 2711 6.8      p < 10−3 0.7 p < 10−3 p < 10−3
Norway 2166      2166 3.1 2159 0.2 2115 4.9 2163 2.3      p < 10−3 0.6 p < 10−3 p < 10−3
Poland 1363      1248 57.9 1343 0.6 1323 57.8 1363 48.9      p < 10−3 1 p < 10−3 p < 10−3
Portugal 2907      2888 35.4 2676 1.1 2879 35.0 2907 30.2      0.1 0.3 0.7 p < 10−3
Romania 358      358 64.0 341 17.0 340 17.0 339 17.0      p < 10−3 p < 10−3 0.004 p < 10−3
Slovakia 1333      1332 66.0 1107 2.3 1330 68.2 1333 64.5      p < 10−3 0.02 p < 10−3 p < 10−3
Slovenia 927      927 27.7 926 0.3 927 31.8 927 21.3      0.6 1 0.7 0.3
Spain 4700      4700 15.1 4698 0.7 4697 17.3 4700 12.4      p < 10−3 0.7 p < 10−3 0.003
Sweden 3999      3910 2.7 3999 0.0 3473 3.6 3653 2.3      p < 10−3 0.07 p < 10−3 p < 10−3
United Kingdom 3998      3686 10.3 3441 0.4 3944 7.1 3998 5.5      p < 10−3 1 p < 10−3 p < 10−3
  1. Data from the 2013 European Antimicrobial Resistance Surveillance Network report, www.ecdc.europa.eu/en/publications/Publications/antimicrobial-resistance-surveillance-europe-2013.pdf. Invasive infections are bacteraemia or meningitis
  2. AMC Amoxicillin plus clavulanic acid, TZP Piperacillin-tazobactam, CRO Ceftriaxone, IMP Imipenem, CIP Ciprofloxacin, GM Gentamicin, SXT Trimethoprim-sulphamethoxazole, FT Furan
  3. aThe number of K. pneumoniae strains were estimations based on data presented in the 2013 European Antimicrobial Resistance Surveillance Network report for the other European countries from 2010 to 2013. These calculations were based on the maximum of strains tested for antibiotic susceptibility testing for every year from 2010 to 2013
  4. bAnalyses performed using Pearson Chi Square or Fisher exact tests as appropriate (two-sided tests, p value <0.05 considered as statistically significant). Statistical tests were performed comparing the number of invsiave K. pneumoniae strains resistant to ceftriaxone, imipenem, ciprofloxacin and gentamicin in our study to that of the different countries included in the 2013 European Antimicrobial Resistance Surveillance Network report