In vitro and in vivo antitumor effects of the Egyptian scorpion Androctonus amoreuxi venom in an Ehrlich ascites tumor model

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Table 3 Effect of A. amoreuxi venom on biochemical parameters in serum and liver of EAC-bearing mice

	AST	ALP	Creatinine	GSH	MDA	PCC
Normal control	68.27 ± 0.91	82.74 ± 1.52	0.81 ± 0.07	711.07 ± 2.20	37.80 ± 0.40	2.26 ± 0.43
EAC control	123.82 ± 1.10	165.30 ± 1.14	1.58 ± 0.11	668.94 ± 1.51	45.47 ± 1.28	5.16 ± 0.74
EAC + 1/5 LD₅₀ A. amoreuxi venom	85.08 ± 0.79	90.02 ± 1.30	1.54 ± 0.05	729.90 ± 1.10	32.48 ± 0.41	4.23 ± 0.61
EAC + cisplatin (0.25 mg/kg)	69.34 ± 0.86	99.20 ± 1.73	1.47 ± 0.03	750.98 ± 0.94	35.24 ± 1.01	4.90 ± 0.66
1/5 LD₅₀ A. amoreuxi venom	77.13 ± 1.58^#	135.71 ± 1.02^#	1.51 ± 0.02^#	702.00 ± 7.89^#	35.08 ± 4.06^#	3.99 ± 0.24^#

Data are presented as mean ± SEM (six animals/group)
^#Significant difference between animal groups (normal control EAC control, EAC + 1/5 LD₅₀ A. amoreuxi venom, EAC + cisplatin and 1/5 LD₅₀ A. amoreuxi venom) using one-way ANOVA (P ≤ 0.05) followed by a Tukey post hoc test for multiple comparisons