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Table 6 Correlation between total vitamin B12 and HoloTC

From: Holotranscobalamin (HoloTC, Active-B12) and Herbert’s model for the development of vitamin B12 deficiency: a review and alternative hypothesis

Reference

HoloTC versus B12 correlation coefficient (r)

Al Aisari et al. (2010)

0.765

Augoustides-Savvopoulou et al. (2007)

0.882

Bamonti et al. (2010)

0.42

Čabarkapa et al. (2007)

0.53

Chen et al. (2005)

0.45

Clarke et al. (2007)

0.61

Fragasso et al. (2012)

0.64

Goringe et al. (2006)

0.63 (r2 = 0.397)

Herrmann et al. (2003a)

0.75

Herrmann and Obeid (2013)

0.577 (whole), 0.524 (low B12), 0.403 (high B12)

Hvas and Nexo (2005)

0.71

Lee et al. (2009)

0.6591

Lloyd-Wright et al. (2003)

0.75

Lobreglio et al. (2008)

0.495

Loikas et al. (2003)

0.80

Loikas (2007)

0.78

Nexo et al. (2002b)

0.45

Palacios et al. (2013)

0.65

Refsum et al. (2006)

0.65 (male), 0.61 (female)

Schrempf et al. (2011)

0.577–0.637

Scott et al. (2007)

0.5

Vanpoucke et al. (2007)

0.53 (r2 = 0.28)

  1. Herrmann and Obeid (2013) reported three values for r: for the whole range of total vitamin B12; for low values of vitamin B12; for high values of vitamin B12
  2. Refsum et al. (2006) reported separate values for r for males and females