Table 2 Sensitivity and specificity—HoloTC versus B₁₂—original research data

Bamonti et al. (2010)

0.74

0.52

HoloTC < 40 pmol/L

0.75

Clarke et al. (2007) (definite deficiency)

0.771 versus 0.757

0.761 versus 0.724

MMA > 0.75 μmol/L

0.85 versus 0.76

Clarke et al. (2007) (probable deficiency)

0.647 versus 0.626

0.792 versus 0.748

MMA > 0.45 μmol/L

0.79 versus 0.87

Goringe et al. (2006)

HoloTC < 38 pmol/L

0.75 versus 0.72

Heil et al. (2012)

0.83 versus 0.64

0.60 versus 0.64

MMA > 0.45 μmol/L

0.78 versus 0.70

Herrmann et al. (2003a)

0.87 versus 0.45

0.75 versus 0.98

MMA > 0.271 μmol/L

0.879 versus 0.836

Herrmann and Obeid (2013)

0.72 versus 0.72

0.54 versus 0.41

MMA > 0.300 μmol/L

0.714 versus 0.632

Hvas and Nexo (2003)

1.0

0.89

Hvas and Nexo (2005)

MMA > 0.75 μmol/L

0.90 versus 0.85

Lindemans et al. (2007)

MMA > 0.26 μmol/L

0.80 versus 0.68

Lloyd-Wright et al. (2003)

MMA > 0.75 μmol/L

0.87 versus 0.86

Miller et al. (2006)

holoTC < 35 pmol/L

0.828 versus 0.816

Obeid and Herrmann (2007a)

0.72

MMA > 0.300 μmol/L

0.71 versus 0.60

Palacios et al. (2013)

0.44 versus 0.20

0.94 versus 0.94

HoloTC < 35 pmol/L

0.75 versus 0.69

Schrempf et al. (2011)

0.563 versus 0.662

0.505 versus 0.621

MMA > 47 μg/L

0.66 versus 0.72

Scott et al. (2007)

MMA > 0.75 μmol/L

0.85 versus 0.75, 0.74, 0.72

Valente et al. (2011)

0.55 versus 0.33

0.96 versus 0.95

Red cell cobalamin <33 pmol/L

0.90 versus 0.80