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Table 1 Effects of the administration to mice of cationic amino acids on potassium levels in brain, heart, spleen, skeletal muscle, kidney and testis

From: Tissue-specific regulation of potassium homeostasis by high doses of cationic amino acids

  Control Arginine HCl Lysine HCl Ornithine HCl
Brain 95.05 ± 1.4 103.5 ± 1.3** 110.4 ± 1.9*** 108.6 ± 1.5***
Heart 75.60 ± 1.6 77.50 ± 3.0 87.60 ± 2.9* 86.20 ± 3.9*
Spleen 111.8 ± 1.7 103.6 ± 2.8 105.1 ± 2.6 113.3 ± 3.0
Muscle 97.05 ± 2.2 101.1 ± 2.9 102.3 ± 3.2 99.20 ± 2.0
Kidney 70.20 ± 2.2 68.80 ± 2.2 63.20 ± 1.1* 54.60 ± 2.5*
Testis 80.20 ± 1.3 90.60 ± 3.7* 96.00 ± 2.9* N.D.
  1. l-Arginine HCl, l-lysine HCl and l-ornithine HCl (4 g/kg) were given intraperitoneally (two injections, 1 h apart) and tissue potassium was determined 2 h after the last injection. Results are given as mean ± SE from a minimum of six animals per group, and are expressed as µmol/g
  2. ND not determined
  3. Statistical significance: (*) P < 0.05 versus control; (**) P < 0.01 versus control; (***) P < 0.001 versus control