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Table 1 Effects of the administration to mice of cationic amino acids on potassium levels in brain, heart, spleen, skeletal muscle, kidney and testis

From: Tissue-specific regulation of potassium homeostasis by high doses of cationic amino acids

 

Control

Arginine HCl

Lysine HCl

Ornithine HCl

Brain

95.05 ± 1.4

103.5 ± 1.3**

110.4 ± 1.9***

108.6 ± 1.5***

Heart

75.60 ± 1.6

77.50 ± 3.0

87.60 ± 2.9*

86.20 ± 3.9*

Spleen

111.8 ± 1.7

103.6 ± 2.8

105.1 ± 2.6

113.3 ± 3.0

Muscle

97.05 ± 2.2

101.1 ± 2.9

102.3 ± 3.2

99.20 ± 2.0

Kidney

70.20 ± 2.2

68.80 ± 2.2

63.20 ± 1.1*

54.60 ± 2.5*

Testis

80.20 ± 1.3

90.60 ± 3.7*

96.00 ± 2.9*

N.D.

  1. l-Arginine HCl, l-lysine HCl and l-ornithine HCl (4 g/kg) were given intraperitoneally (two injections, 1 h apart) and tissue potassium was determined 2 h after the last injection. Results are given as mean ± SE from a minimum of six animals per group, and are expressed as µmol/g
  2. ND not determined
  3. Statistical significance: (*) P < 0.05 versus control; (**) P < 0.01 versus control; (***) P < 0.001 versus control