Fig. 1

Images of the right eye and left eye of Patient 1 at diagnosis of VKH disease. a, b Color fundus photograph. Left eye shows serous retinal detachment. c Early-phase fluorescein angiogram (FA) of the right eye shows hyperfluorescent dots. d Early-phase FA of the left eye shows multiple punctuate hyperfluorescent lesions on the retinal pigment epithelium (RPE) and multiple small round hypofluorescent lesions, suggesting uneven filling of the choriocapillaris (dark areas). e, f Mid-phase FA (2 min) and late-phase FA (7 min) of the left eye shows multilobular pools of dye. Foveal round area of the dye pooling has a dark rim. g Enhanced depth imaging optical coherence tomography (EDI-0CT) of the right eye shows choroidal hyperreflectivity. Chroidal thickness = 436 µm (OD). h EDI-OCT of the left eye shows serous retinal detachment, subretinal cystoid spaces, and subretinal septa (white arrow) separating the cystoid space from subretinal fluid. The subretinal cystoid spaces are slightly more reflective than the area of serous retinal detachment. Retinal thickness = 1246 µm (OS). Enlargement of the choroid of the left eye is not visible on EDI-OCT at this stage