Fig. 5
a–d Liver tissue in acute obstructive cholangitis (AOC) group at 3,6,12 and 24 h (HE × 400). Many inflammatory infiltration mainly consisting of neutrophil and expansion of central veins are found at 3 h. Focal inflammation are found in liver parenchyma at 6 h. Obvious expansion of portal area, massive mixing inflammatory cells infiltration are found at 12 h. Large-area hepatocyte degeneration and necrosis are found at 24 h. e Liver tissue in Bile Duct Ligation (BDL) group (HE × 400), Manipulus Inflammatory cells infiltration are found in portal area. f Liver tissue in Sham Operation (SO) group (HE × 400), no obvious histopathological changes are found in liver tissue