Skip to main content
SpringerPlus

Table 6 Comparison of FINS, FPG and HOMA indices according to the genotypes of MG53 in Yixing population

From: Evaluation of common variants in MG53 and the risk of type 2 diabetes and insulin resistance in Han Chinese

Group

Variable

rs7186832

rs12929077

TT

TC

CC

AA

AG

GG

NGT

n

1836

910

99

1681

1019

127

FINS (mU/L)

5.76 ± 4.38

5.75 ± 4.47

5.21 ± 3.90

5.77 ± 4.42

5.72 ± 4.42

5.29 ± 3.60

FPG (mmol/L)

4.89 ± 0.59

4.90 ± 0.58

4.80 ± 0.61

4.90 ± 0.59

4.89 ± 0.58

4.87 ± 0.51

HOMA-β

80.86 ± 309.33

85.29 ± 133.71

65.35 ± 110.37

80.18 ± 322.51

84.92 ± 128.53

71.46 ± 99.74

HOMA-IR

1.26 ± 0.97

1.27 ± 1.03

1.13 ± 0.90

1.27 ± 0.98

1.26 ± 1.01

1.15 ± 0.80

HOMA-IS

0.066 ± 0.099

0.066 ± 0.921

0.662 ± 0.096

0.06 ± 0.10

0.65 ± 0.86

0.65 ± 0.64

IFG

n

569

281

25

520

313

36

FINS (mU/L)

7.12 ± 5.43

7.89 ± 7.30

6.80 ± 3.89

6.89 ± 4.86

8.22 ± 7.76*

6.33 ± 3.28

FPG (mmol/L)

6.02 ± 0.34

6.07 ± 0.38

5.96 ± 0.34

6.02 ± 0.34

6.07 ± 0.37

5.95 ± 0.34

HOMA-β

57.07 ± 43.80

61.48 ± 53.29

55.58 ± 33.25

55.07 ± 38.38

64.64 ± 59.11

51.18 ± 23.93

HOMA-IR

1.91 ± 1.47

2.14 ± 2.07

1.81 ± 1.06

1.85 ± 1.33

2.22 ± 2.16*

1.69 ± 0.95

HOMA-IS

0.038 ± 0.041

0.037 ± 0.047

0.034 ± 0.016

0.039 ± 0.042

0.036 ± 0.045

0.033 ± 0.017

T2D (untreated)

n

230

96

15

197

119

21

FINS (mU/L)

8.99 ± 7.88

11.72 ± 13.88

13.75 ± 16.51

8.81 ± 8.05

10.66 ± 11.59*

14.29 ± 14.70

FPG (mmol/L)

9.74 ± 3.14

9.73 ± 3.36

8.67 ± 1.86

9.72 ± 3.16

9.88 ± 3.39

8.88 ± 1.67

HOMA-β

35.11 ± 39.20

48.84 ± 72.56

67.50 ± 94.10

35.31 ± 41.75

40.83 ± 51.27*

63.03 ± 78.67

HOMA-IR

4.06 ± 4.05

5.09 ± 5.90

4.79 ± 5.24

3.93 ± 4.03

4.86 ± 5.44*

5.35 ± 5.18

HOMA-IS

0.024 ± 0.028

0.020 ± 0.020

0.026 ± 0.037

0.026 ± 0.032

0.018 ± 0.017*

0.021 ± 0.021

T2D (treated)

n

104

44

8

95

53

8

FINS (mU/L)

8.21 ± 6.01

10.23 ± 10.94

12.09 ± 14.30

8.47 ± 6.45

11.03 ± 13.38

8.88 ± 4.42

FPG (mmol/L)

9.27 ± 3.56

8.80 ± 3.08

9.95 ± 2.93

9.03 ± 3.27

9.25 ± 3.69

10.01 ± 2.95

HOMA-β

41.6847.68

52.81 ± 72.15

41.99 ± 53.95

45.12 ± 50.91

54.97 ± 88.74

30.30 ± 13.73

HOMA-IR

3.52 ± 3.83

3.88 ± 4.11

5.25 ± 5.64

3.40 ± 3.31

4.50 ± 5.49

4.01 ± 4.15

HOMA-IS

0.025 ± 0.029

0.026 ± 0.026

0.021 ± 0.021

0.25 ± 0.029

0.027 ± 0.026

0.016 ± 0.012

  1. Comparison of FINS, FPG, HOMA-β, HOMA-IR, HOMA-IS between genotypes rs7186832 and rs12929077 were adjusted for age, gender and BMI by general linear regression; Significant P value (P < 0.05) was observed and marker by “*” for comparing AG to AA of rs12929077, a linear increase in insulin was observed with the variants of rs12929077 (P = 0.013) in untreated T2D subjects. FINS, HOMA-β, HOMA-IR, HOMA-IS are log-transformed for comparison
  2. NGT normal glucose tolerance, IFG impaired fasting glucose, T2D type 2 diabetes, n number of subjects, BMI body mass index, FPG fasting plasma glucose, FINS fasting insulin, HOMA homeostasis model assessment, IR insulin resistance, IS insulin sensitivity
Back to article page