Evaluation of common variants in MG53 and the risk of type 2 diabetes and insulin resistance in Han Chinese

SpringerPlus

Table 3 Stratification analysis of MG53 rs7186832 and rs12929077 with T2D in Nantong population

SNP	Gender	Group	WT/Ht/MT	Additive model (WT vs Ht vs MT)			Dominant model (WT vs Ht + MT)
SNP	Gender	Group	WT/Ht/MT	OR (95 % CI)^a	OR (95 % CI)^b	OR (95 % CI)^c	OR (95 % CI)^a	OR (95 % CI)^b	OR (95 % CI)^c
rs7186832			TT/TC/CC
	Male	NGT	204/115/12	0.83 (0.65–1.05)	0.83 (0.65–1.06)	0.96 (0.74–1.24)	0.75 (0.57–0.99)	0.77 (0.58–1.02)	0.91 (0.67–1.23)
		IGT	125/47/8	P = 0.121	P = 0.136	P = 0.743	P = 0.049	P = 0.071	P = 0.538
		T2D	171/67/10
	Female	NGT	433/167/26	1.15 (0.97–1.36)	1.14 (0.97–1.36)	1.36 (1.12–1.63)	1.25 (1.03–1.53)	1.25 (1.03–1.54)	1.58 (1.27–1.96)
		IGT	235/95/12	P = 0.114	P = 0.177	P = 0.001	P = 0.024	P = 0.026	P = 3.9 × 10⁻⁵
		T2D	331/180/16
rs12929077			AA/AG/GG
	Male	NGT	184/133/14	0.84 (0.66–1.06)	0.83 (0.65–1.05)	0.94 (0.73–1.22)	0.80 (0.61–1.04)	0.80 (0.61–1.05)	0.82 (0.67–1.24)
		IGT	111/63/5	P = 0.138	P = 0.124	P = 0.641	P = 0.107	P = 0.112	P = 0.580
		T2D	154/85/10
	Female	NGT	386/210/27	1.07 (0.91–1.27)	1.09 (0.92–1.28)	1.24 (1.03–1.47)	1.12 (0.93–1.39)	1.14 (0.94–1.39)	1.34 (1.08–1.65)
		IGT	209/119/11	P = 0.407	P = 0.329	P = 0.019	P = 0.225	P = 0.172	P = 0.006
		T2D	305/198/19

SNP single nuclear polymorphisms, WT wild type, Ht heterozygote, MT mutant type, OR odds ratio, CI confidence interval, NGT normal glucose tolerance, IFG impaired fasting glucose, P probability, T2D type 2 diabetes
^aP value of χ² test for comparison of genotype between case and control groups
^bOrdinal multinomial logistic regression analysis adjusted for age, gender and PAI
^cOrdinal multinomial logistic regression analysis adjusted for age, gender, BMI and PAI