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Table 2 The pharmacokinetic properties of the available triptans

From: Recent advances in migraine therapy

Drug Formulation Dosage (mg) Maximum 24 h dose (mg) Time of peak levels Elimination half life (H) Bioavailability (%)
Sumatriptan SI 6 6 12 min 2 97
OT 50–100 200 2–3 h 2 15
NS 20 40 1 h 2 17
Rizatriptan ODT 10 30 1–2 h 2 14
Zolmitriptan ODT 2.5 10 3 h 2.5–3 40–50
Almotriptan OT 12.5 12.5 1.5–2 h 3.5 70
Eletriptan OT 40 80 1.5–2 h 4 50
Naratriptan OT 2.5 5 2–3 h 6 60–70
frovatriptan OT 2.5 7.5 2–4 h 26 20–40
  1. SI subcutaneous injection, OT oral tablet, NS nasal spray, ODT oral dispersible tablet, min minutes, h hour