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Table 2 The pharmacokinetic properties of the available triptans

From: Recent advances in migraine therapy

Drug

Formulation

Dosage (mg)

Maximum 24 h dose (mg)

Time of peak levels

Elimination half life (H)

Bioavailability (%)

Sumatriptan

SI

6

6

12 min

2

97

OT

50–100

200

2–3 h

2

15

NS

20

40

1 h

2

17

Rizatriptan

ODT

10

30

1–2 h

2

14

Zolmitriptan

ODT

2.5

10

3 h

2.5–3

40–50

Almotriptan

OT

12.5

12.5

1.5–2 h

3.5

70

Eletriptan

OT

40

80

1.5–2 h

4

50

Naratriptan

OT

2.5

5

2–3 h

6

60–70

frovatriptan

OT

2.5

7.5

2–4 h

26

20–40

  1. SI subcutaneous injection, OT oral tablet, NS nasal spray, ODT oral dispersible tablet, min minutes, h hour