TY - JOUR AU - Kowalska, Karolina AU - Piastowska-Ciesielska, Agnieszka Wanda PY - 2016 DA - 2016/04/26 TI - Oestrogens and oestrogen receptors in prostate cancer JO - SpringerPlus SP - 522 VL - 5 IS - 1 AB - The role of androgens in prostate cancer is obvious due to the fact that androgen signalling is the main regulator of prostate growth and function. Androgen deprivation therapy is a mainstay treatment for advanced prostate cancer. However, prostate cancer often becomes androgen-independent, which in consequence leads to lethal and incurable disease. In addition, oestrogens play a crucial role in prostate cancer, especially in elder men in whom the overall ratio of oestrogens to androgens is increasing. This review summarizes the current knowledge on molecular mechanisms through which oestrogens are involved in prostate cancer development. We focused on commonly alternated molecular signalling pathways contributing to tumourgenesis in prostate cancer. SN - 2193-1801 UR - https://doi.org/10.1186/s40064-016-2185-6 DO - 10.1186/s40064-016-2185-6 ID - Kowalska2016 ER -