Clinical value of preoperative serum CA 19-9 and CA 125 levels in predicting the resectability of hilar cholangiocarcinoma

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Table 3 Analyzing the relationship of preoperative factors with the resectability rate in those with potentially resectable tumors judged by radiologic examination with normal bilirubin levels

Variable	Resectable (n = 98)	Unresectable (n = 40)	P value
Age^a
≤60	46 (46.9)	25 (62.5)	NS
>60	52 (53.1)	15 (37.5)
Gender
Female	47 (48)	26 (65)	NS
Male	51 (52)	14 (35)
Symptom presentation
No	38 (38.8)	18 (45)	NS
Yes	60 (61.2)	22 (55)
Preoperative hospital stay >7 days^a
No	62 (63.3)	20 (52.6)	NS
Yes	36 (36.7)	18 (47.4)
Preoperative CA 19-9 >200 U/ml^b
No	82 (83.7)	8 (20)	<0.001
Yes	16 (16.3)	32 (80)
Preoperative CA 125 >26 U/ml^b
No	77 (78.6)	13 (32.5)	<0.001
Yes	21 (21.4)	27 (67.5)
Preoperative CEA >3.4 ng/ml^b
No	59 (60.2)	22 (55)	NS
Yes	39 (39.8)	18 (45)
Preoperative ALT level >50 U/l^c
No	25 (25.5)	16 (40)	NS
Yes	73 (74.5)	24 (60)
Preoperative AST level >40 U/l^c
No	21 (21.4)	11 (27.5)	NS
Yes	77 (78.6)	29 (72.5)
Preoperative albumin level >40 g/l^c
No	63 (64.3)	20 (50)	NS
Yes	35 (35.7)	20 (50)
Tumor size^d
≤3 cm	76 (77.6)	18 (45)	<0.001
>3 cm	22 (22.4)	22 (55)
BMI^a
≤21 kg/m²	66 (67.3)	19 (47.5)	0.03
>21 kg/m²	32 (32.7)	21 (52.5)
Bismuth–Corlette classification
I and II	61 (62.2)	16 (40)	0.017
III and IV	37 (37.8)	24 (60)

NS not significant, CA 19-9 carbohydrate antigenic determinant 19-9, CA 125 carbohydrate antigen 125, CEA carcino embryonie antigen, ALT alanine aminotransferase, AST aspartate transaminase, BIM body mass index
^aUsing the median value
^bUsing the the best cut-off point in ROC analysis
^cUsing the lowing limit of the normal range
^dUsing the cut-off recommended in the DeOliveira staging system