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Table 3 Analyzing the relationship of preoperative factors with the resectability rate in those with potentially resectable tumors judged by radiologic examination with normal bilirubin levels

From: Clinical value of preoperative serum CA 19-9 and CA 125 levels in predicting the resectability of hilar cholangiocarcinoma

Variable Resectable (n = 98) Unresectable (n = 40) P value
Agea
 ≤60 46 (46.9) 25 (62.5) NS
 >60 52 (53.1) 15 (37.5)  
Gender
 Female 47 (48) 26 (65) NS
 Male 51 (52) 14 (35)  
Symptom presentation
 No 38 (38.8) 18 (45) NS
 Yes 60 (61.2) 22 (55)  
Preoperative hospital stay >7 daysa
 No 62 (63.3) 20 (52.6) NS
 Yes 36 (36.7) 18 (47.4)  
Preoperative CA 19-9 >200 U/mlb
 No 82 (83.7) 8 (20) <0.001
 Yes 16 (16.3) 32 (80)  
Preoperative CA 125 >26 U/mlb
 No 77 (78.6) 13 (32.5) <0.001
 Yes 21 (21.4) 27 (67.5)  
Preoperative CEA >3.4 ng/mlb
 No 59 (60.2) 22 (55) NS
 Yes 39 (39.8) 18 (45)  
Preoperative ALT level >50 U/lc
 No 25 (25.5) 16 (40) NS
 Yes 73 (74.5) 24 (60)  
Preoperative AST level >40 U/lc
 No 21 (21.4) 11 (27.5) NS
 Yes 77 (78.6) 29 (72.5)  
Preoperative albumin level >40 g/lc
 No 63 (64.3) 20 (50) NS
 Yes 35 (35.7) 20 (50)  
Tumor sized
 ≤3 cm 76 (77.6) 18 (45) <0.001
 >3 cm 22 (22.4) 22 (55)  
BMIa
 ≤21 kg/m2 66 (67.3) 19 (47.5) 0.03
 >21 kg/m2 32 (32.7) 21 (52.5)  
Bismuth–Corlette classification
 I and II 61 (62.2) 16 (40) 0.017
 III and IV 37 (37.8) 24 (60)  
  1. NS not significant, CA 19-9 carbohydrate antigenic determinant 19-9, CA 125 carbohydrate antigen 125, CEA carcino embryonie antigen, ALT alanine aminotransferase, AST aspartate transaminase, BIM body mass index
  2. aUsing the median value
  3. bUsing the the best cut-off point in ROC analysis
  4. cUsing the lowing limit of the normal range
  5. dUsing the cut-off recommended in the DeOliveira staging system