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Table 2 ROC analysis of tumor markers to predict resectability of patients with potentially resectable hilar cholangiocarcinoma judged by radiologic examination

From: Clinical value of preoperative serum CA 19-9 and CA 125 levels in predicting the resectability of hilar cholangiocarcinoma

Parameter For all patients (n = 471) For normal bilirubin patients (n = 138)
CEA CA 125 CA 19-9 CEA CA 125 CA 19-9
Cut-off value 4.37 26.84 200.4 3.36 25.905 203.96
ROC area 0.659 0.785 0.815 0.542 0.730 0.825
95 % CI 0.604–0.713 0.740–0.829 0.773–0.857 0.425–0.659 0.629–0.830 0.736–0.913
Sensitivity (%) 74.4 77 71.2 60.2 78.6 83.7
Specificity (%) 52.5 71 88.3 45 67.5 80
PPV (%) 74.9 83.2 92.1 72.8 85.6 91.1
NPV (%) 51.8 61.6 61.6 31.6 56.2 66.7
  1. ROC receiver operating characteristic, PPV positive predictive value, NPV negative predictive value, CA 19-9 carbohydrate antigenic determinant 19-9, CA 125 carbohydrate antigen 125, CEA carcino embryonie antigen