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Table 2 Meta-analysis results of the association of the MMP-9 promoter −1562 C/T polymorphism with CP risk

From: A meta-analysis of MMP-9 promoter −1562 C/T polymorphism on susceptibility of chronic periodontitis

MMP-9 (−1562 C/T)

Studies (cases/controls)

T versus C

OR (95 % CI), P

Ph, I 2 (%)

TT versus CC

OR (95 % CI), P

Ph, I 2 (%)

CT versus CC

OR (95 % CI), P

Ph, I 2 (%)

Dominant genetic model

OR (95 % CI), P

Ph, I 2 (%)

Recessive genetic model

OR (95 % CI), P

Ph, I 2(%)

Total

7 (859/1186)

0.49 (0.31–0.77), 0.002

0.001, 85.8

0.16 (0.12–0.22), 0.001

0.564, 0.0

0.53 (0.33–0.85), 0.008

0.001, 73.4

0.46 (0.26–0.82), 0.009

0.001, 85.8

0.27 (0.20–0.35), 0.001

0.897, 0.0

Ethnicity

 Caucasian

3 (326/312)

0.61 (0.39–0.97), 0.037

0.101, 56.3

0.35 (0.13–0.97), 0.044

0.452, 0.0

0.66 (0.47–0.92), 0.016

0.227, 32.5

0.62 (0.45–0.87), 0.005

0.139, 49.3

0.40 (0.14–1.10), 0.076

0.535, 0.0

 Asian

2 (402/782)

0.26 (0.21–0.31), 0.001

0.902, 0.0

0.14 (0.10–0.20), 0.001

0.926, 0.0

0.27 (0.19–0.39), 0.001

0.522, 0.0

0.19 (0.14–0.26), 0.001

0.756, 0.0

0.26 (0.20–0.35), 0.001

0.782, 0.0

 Mixed

2 (131/92)

0.89 (0.49–1.59), 0.684

0.596, 0.0

0.23 (0.02–2.25), 0.206

0.883, 0.0

1.09 (0.56–2.11), 0.808

0.453, 0.0

0.98 (0.51–1.88), 0.953

0.512, 0.0

0.23 (0.02–2.22), 0.202

0.915, 0.0

Severity of chronic periodontitis

 Severe

6 (687/1132)

0.46 (0.28–0.75), 0.002

0.001, 87.6

0.16 (0.12–0.22), 0.001

0.260. 23.2

0.48 (0.29–0.81), 0.006

0.001, 75.9

0.41 (0.21–0.78), 0.006

0.001, 87.2

0.27 (0.21–0.36), 0.001

0.680, 0.0

 Moderate

2 (103/173)

0.65 (0.40–1.07), 0.090

0.358, 0.0

0.34 (0.06–2.08), 0.245

0.831, 0.0

0.70 (0.39–1.24), 0.218

0.319, 0.0

0.65 (0.37–1.14), 0.132

0.323, 0.0

0.37 (0.06–2.26), 0.284

0.891, 0.0

  1. MMP-9: matrix metalloproteinase-9; CP: chronic periodontitis; dominant genetic model: TT + CT versus CC; recessive genetic model: TT versus CT + CC; Ph: the P value of heterogeneity; OR: odds ratio; CI: confidence interval
  2. When Ph is < 0.1 and I 2 exceeded 50 %, the random-effects modelwas used. Conversely, the fixed-effects model was used