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Table 2 Meta-analysis results of the association of the MMP-9 promoter −1562 C/T polymorphism with CP risk

From: A meta-analysis of MMP-9 promoter −1562 C/T polymorphism on susceptibility of chronic periodontitis

MMP-9 (−1562 C/T) Studies (cases/controls) T versus C
OR (95 % CI), P
Ph, I 2 (%)
TT versus CC
OR (95 % CI), P
Ph, I 2 (%)
CT versus CC
OR (95 % CI), P
Ph, I 2 (%)
Dominant genetic model
OR (95 % CI), P
Ph, I 2 (%)
Recessive genetic model
OR (95 % CI), P
Ph, I 2(%)
Total 7 (859/1186) 0.49 (0.31–0.77), 0.002
0.001, 85.8
0.16 (0.12–0.22), 0.001
0.564, 0.0
0.53 (0.33–0.85), 0.008
0.001, 73.4
0.46 (0.26–0.82), 0.009
0.001, 85.8
0.27 (0.20–0.35), 0.001
0.897, 0.0
Ethnicity
 Caucasian 3 (326/312) 0.61 (0.39–0.97), 0.037
0.101, 56.3
0.35 (0.13–0.97), 0.044
0.452, 0.0
0.66 (0.47–0.92), 0.016
0.227, 32.5
0.62 (0.45–0.87), 0.005
0.139, 49.3
0.40 (0.14–1.10), 0.076
0.535, 0.0
 Asian 2 (402/782) 0.26 (0.21–0.31), 0.001
0.902, 0.0
0.14 (0.10–0.20), 0.001
0.926, 0.0
0.27 (0.19–0.39), 0.001
0.522, 0.0
0.19 (0.14–0.26), 0.001
0.756, 0.0
0.26 (0.20–0.35), 0.001
0.782, 0.0
 Mixed 2 (131/92) 0.89 (0.49–1.59), 0.684
0.596, 0.0
0.23 (0.02–2.25), 0.206
0.883, 0.0
1.09 (0.56–2.11), 0.808
0.453, 0.0
0.98 (0.51–1.88), 0.953
0.512, 0.0
0.23 (0.02–2.22), 0.202
0.915, 0.0
Severity of chronic periodontitis
 Severe 6 (687/1132) 0.46 (0.28–0.75), 0.002
0.001, 87.6
0.16 (0.12–0.22), 0.001
0.260. 23.2
0.48 (0.29–0.81), 0.006
0.001, 75.9
0.41 (0.21–0.78), 0.006
0.001, 87.2
0.27 (0.21–0.36), 0.001
0.680, 0.0
 Moderate 2 (103/173) 0.65 (0.40–1.07), 0.090
0.358, 0.0
0.34 (0.06–2.08), 0.245
0.831, 0.0
0.70 (0.39–1.24), 0.218
0.319, 0.0
0.65 (0.37–1.14), 0.132
0.323, 0.0
0.37 (0.06–2.26), 0.284
0.891, 0.0
  1. MMP-9: matrix metalloproteinase-9; CP: chronic periodontitis; dominant genetic model: TT + CT versus CC; recessive genetic model: TT versus CT + CC; Ph: the P value of heterogeneity; OR: odds ratio; CI: confidence interval
  2. When Ph is < 0.1 and I 2 exceeded 50 %, the random-effects modelwas used. Conversely, the fixed-effects model was used