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Table 1 Baseline characteristics of studies included for investigating the association of the MMP-9 promoter −1562 C/T polymorphism with periodontitis risk

From: A meta-analysis of MMP-9 promoter −1562 C/T polymorphism on susceptibility of chronic periodontitis

References Country Ethnicity Sample size (case/control) Type of periodontitis Matching criteria Genotype method HWE in controls
de Souza et al. (2005) Brazil Mixed 62/38 Moderate or severe CP PCR–RFLP 0.623
Holla et al. (2006) Czech Caucasian 169/135 Moderate or severe CP Age, gender, smoker ratios PCR–RFLP 0.586
Keles et al. (2006) Turkey Caucasian 70/70 Severe CP Age, gender PCR–RFLP 0.816
Gurkan et al. (2008) Turkey Caucasian 87/107 Severe CP Age, gender,smoker ratios PCR–RFLP 0.017
Loo et al. (2011) China Asian 280/250 Severe CP Age, gender PCR–RFLP 0.001
Isaza-Guzman et al. (2011) Colombia Mixed 69/54 Slight to moderate to severe CP Gender PCR–RFLP 0.163
Li et al. (2012) China Asian 122/532 Severe CP PCR–RFLP 0.001
  1. MMP-9 matrix metalloproteinase-9, CP chronic periodontitis, GAgP generalized aggressive periodontitis, HWE Hardy–Weinberg equilibrium
  2. Slight periodontitis: patients with teeth exhibiting <3 mm attachment loss; moderate periodontitis: patients with teeth exhibiting ≥3 and <7 mm attachment loss; severe periodontitis: patients with teeth exhibiting ≥7 mm attachment loss
  3. A P value less than 0.05 of HWE was considered significant