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Fig. 3 | SpringerPlus

Fig. 3

From: Central antinociceptive activity of peripherally applied botulinum toxin type A in lab rat model of trigeminal neuralgia

Fig. 3

Axonal transport blocker colchicine blocked antinociceptive effects of BoNT-A (10 U/kg). Rats underwent either ION-CCI or sham operation. Injection of BoNT-A (3, 10 U/kg) or normal saline into the whisker pad ipsilateral to the operation site was performed 14 days after the operation. Colchicine or normal saline was injected into ipsilateral trigeminal ganglion 12 h before the application of BoNT-A. TG indicates injection into the trigeminal ganglion; WP indicates injection into the facial whisker pad. *P < 0.05 versus CCI + saline(TG) + BoNT-A(WP) group

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