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Table 3 Genetic risk score (GRS) and cognitive function composite regression analysis results

From: Polymorphisms in DNA repair and oxidative stress genes associated with pre-treatment cognitive function in breast cancer survivors: an exploratory study

Composite cognitive function composite

Gene-SNP used in GRS calculation

Minor allele

Wildtype reference allele

bGRS

Model R2

R2 change for GRS

Attentiona (n = 214)

ERCC3-rs2134794

C

A

1.003*

0.236

0.048

ERCC5-rs873601

G

A

Concentration (n = 206)

ERCC2-rs3916874

C

G

0.619*

0.218

0.150

ERCC2-rs50872

T

C

ERCC3-rs2134794

C

A

ERCC3-rs4150407

G

A

ERCC5-rs2296147

C

T

SOD2-rs4880

T

C

SOD2-rs5746136

A

G

SOD2-rs8031

T

A

Executive functiona

(n = 215)

ERCC3-rs2134794

C

A

0.535*

0.299

0.075

ERCC3-rs4150407

G

A

ERCC3-rs4150477

T

C

ERCC5-rs2296147

C

T

PARP1-rs2271347

A

G

PARP1-rs3219058

A

G

Mental flexibilitya (n = 198)

ERCC2-rs13181

G

T

0.669*

0.342

0.094

ERCC3-rs4150407

G

A

ERCC3-rs4150477

T

C

PARP1-rs2271347

C

T

SEPP1-rs230819

A

C

SEPP1-rs3877899

A

G

SOD1-rs1041740

T

C

Psychomotor speeda

(n = 186)

CAT-rs511895

A

G

0.741*

0.288

0.126

CAT-rs769214

G

A

ERCC5-rs11069498

G

A

ERCC5-rs2296148

T

C

 

ERCC5-rs751402

T

C

ERCC5-rs873601

G

A

SEPP1-rs3877899

A

G

SOD1-rs1041740

T

C

Verbal memory (n = 214)

CAT-rs566979

G

T

0.567*

0.289

0.049

ERCC5-rs11069498

G

A

ERCC5-rs4150360

C

T

ERCC5-rs751402

T

C

Visual memorya (n = 178)

CAT-rs1001179

A

G

0.691*

0.260

0.118

CAT-rs525938

G

A

CAT-rs566979

G

T

CAT-rs769214

G

A

ERCC5-rs751402

T

C

GPX1-rs1050450

G

A

Visual working memorya (n = 210)

ERCC2-rs1799787

T

C

0.766*

0.256

0.111

ERCC5-rs11069498

G

A

ERCC5-rs4150355

T

C

ERCC5-rs4150360

C

T

ERCC5-rs873601

G

A

PARP1-rs2271347

C

T

  1. SNP single nucleotide polymorphism, GRS genetic risk score. All regression models are adjusted for age, estimated verbal intelligence, and levels of depression, anxiety, fatigue, and pain
  2. * p < .001
  3. aGRS calculation based on b-coefficients from regression models with modified influential point values