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Table 3 Genetic risk score (GRS) and cognitive function composite regression analysis results

From: Polymorphisms in DNA repair and oxidative stress genes associated with pre-treatment cognitive function in breast cancer survivors: an exploratory study

Composite cognitive function composite Gene-SNP used in GRS calculation Minor allele Wildtype reference allele bGRS Model R2 R2 change for GRS
Attentiona (n = 214) ERCC3-rs2134794 C A 1.003* 0.236 0.048
ERCC5-rs873601 G A
Concentration (n = 206) ERCC2-rs3916874 C G 0.619* 0.218 0.150
ERCC2-rs50872 T C
ERCC3-rs2134794 C A
ERCC3-rs4150407 G A
ERCC5-rs2296147 C T
SOD2-rs4880 T C
SOD2-rs5746136 A G
SOD2-rs8031 T A
Executive functiona
(n = 215)
ERCC3-rs2134794 C A 0.535* 0.299 0.075
ERCC3-rs4150407 G A
ERCC3-rs4150477 T C
ERCC5-rs2296147 C T
PARP1-rs2271347 A G
PARP1-rs3219058 A G
Mental flexibilitya (n = 198) ERCC2-rs13181 G T 0.669* 0.342 0.094
ERCC3-rs4150407 G A
ERCC3-rs4150477 T C
PARP1-rs2271347 C T
SEPP1-rs230819 A C
SEPP1-rs3877899 A G
SOD1-rs1041740 T C
Psychomotor speeda
(n = 186)
CAT-rs511895 A G 0.741* 0.288 0.126
CAT-rs769214 G A
ERCC5-rs11069498 G A
ERCC5-rs2296148 T C  
ERCC5-rs751402 T C
ERCC5-rs873601 G A
SEPP1-rs3877899 A G
SOD1-rs1041740 T C
Verbal memory (n = 214) CAT-rs566979 G T 0.567* 0.289 0.049
ERCC5-rs11069498 G A
ERCC5-rs4150360 C T
ERCC5-rs751402 T C
Visual memorya (n = 178) CAT-rs1001179 A G 0.691* 0.260 0.118
CAT-rs525938 G A
CAT-rs566979 G T
CAT-rs769214 G A
ERCC5-rs751402 T C
GPX1-rs1050450 G A
Visual working memorya (n = 210) ERCC2-rs1799787 T C 0.766* 0.256 0.111
ERCC5-rs11069498 G A
ERCC5-rs4150355 T C
ERCC5-rs4150360 C T
ERCC5-rs873601 G A
PARP1-rs2271347 C T
  1. SNP single nucleotide polymorphism, GRS genetic risk score. All regression models are adjusted for age, estimated verbal intelligence, and levels of depression, anxiety, fatigue, and pain
  2. * p < .001
  3. aGRS calculation based on b-coefficients from regression models with modified influential point values