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Table 2 MIC/MBC (µg/mL) values of synthesized compounds (13aq) and Cefixime against tested bacterial strains

From: Synthesis, anti-inflammatory, bactericidal activities and docking studies of novel 1,2,3-triazoles derived from ibuprofen using click chemistry

Compounds Gram positive Gram negative
MRSA B. subtilis B. cereus E. coli K. pneumoniae P. vulgaris
MIC MBC MIC MBC MIC MBC MIC MBC MIC MBC MIC MBC
13a >150 >155 109.3 112 118 120 98.6 100 >130 >140 >90 >90
13b 120 126 88.2 >90 102 108 92.6 100 >128 >140 >100 >110
13c 24.1 27.3 28.9 >40 32.0 42.1 28.6 30.2 38.5 >40 >50 >50
13d 30.6 31.6 >25 30.2 45.7 50.1 >40 42.3 62.8 65.2 78.3 80.2
13e 57.9 60.0 60.5 70.2 79.6 82.1 >120 >120 >100 105.1 >150 >150
13f >170 >170 >180 >180 88.1 90.2 112 117 136 138 80.3 85
13g 40.5 42.3 66.6 70.5 >60 68.0 55.3 55.5 33.8 36.9 90.1 >100
13h >118 >120 >140 >140 114 117 >130 <135 175 179 <200 <200
13i 20.5 22.1 18.6 19.3 25.8 30.3 22.5 25.8 35.9 38.0 45.0 >50
13j >188 >190 >153 >160 >160 >160 112 113 >145 >148 >170 >172
13k 33.6 >40 35.9 47.0 44.6 50.2 >50 66.0 58.2 65.0 >80 >86
13l 18.5 24.9 20.5 22.8 20.7 21.0 18.2 24.1 33.6 35.1 30.9 33.5
13m >189 >200 >168 >170 159 163 149 156 177 180 161 164
13n 36.3 39.5 58.0 >80 >60 >75 >50 58.6 80.2 92.0 >70 >85
13o 12.5 15.1 12.9 13.0 12.0 12.0 15.5 20.3 25.3 >30 28.4 >35
13p >120 >120 98.9 102 >140 >150 80.6 92.8 >100 >120 >150 >165
13q >125 >130 >155 158 >160 >160 >110 >115 146 148 133 134
Cefixime <13.5 <13 10.2 11.0 10 10 13.0 13 17 17.2 20.6 21.0
  1. MRSA, Methicillin-resistant Staphylococcus aureus, B. subtilis, Bacillus subtilis, B. cereus, Bacillus cereus, E. coli, Escherichia coli, K. pneumoniae, Klebsiella pneumonia, P. Vulgaris, Proteus vulgaris