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Table 1 In vivo anti-inflammatory activity of novel 1,2,3-triazoles (13aq)

From: Synthesis, anti-inflammatory, bactericidal activities and docking studies of novel 1,2,3-triazoles derived from ibuprofen using click chemistry

Compound 3 h 4 h 5 h 6 h
Swelling Inhibition (%) Swelling Inhibition (%) Swelling Inhibition (%) Swelling Inhibition (%)
Volume of edemac (mL) and % AId
Control (−) 1.17 ± 0.032   1.37 ± 0.012   1.60 ± 0.019   1.89 ± 0.009  
Ibuprofen 0.08 ± 0.021 93.16 0.06 ± 0.027 95.62 0.07 ± 0.027 95.62 0.10 ± 0.021 94.70
13a 0.60 ± 0.015 48.17 0.60 ± 0.004 56.20 0.66 ± 0.004 58.75 0.71 ± 0.012 62.43
13b 0.62 ± 0.024a 47.00 0.61 ± 0.008a 55.47 0.69 ± 0.008a 56.87 0.74 ± 0.016a 60.84
13c 0.17 ± 0.020 85.47 0.17 ± 0.016 87.59 0.21 ± 0.009 86.87 0.26 ± 0.011 86.24
13d 0.50 ± 0.007 57.26 0.49 ± 0.019 64.23 0.54 ± 0.009 66.25 0.56 ± 0.015 70.37
13e 0.43 ± 0.011 63.24 0.42 ± 0.023 69.34 0.53 ± 0.013 66.87 0.62 ± 0.018 67.19
13f 0.54 ± 0.015 53.84 0.54 ± 0.010 60.58 0.57 ± 0.019 64.37 0.62 ± 0.011 67.19
13g 0.15 ± 0.017a 87.17 0.12 ± 0.007a 91.24 0.15 ± 0.014a 90.62 0.20 ± 0.012a 89.41
13h 0.40 ± 0.022 65.81 0.49 ± 0.012 64.23 0.56 ± 0.017 65.00 0.60 ± 0.011 68.25
13i 0.23 ± 0.009b 80.34 0.20 ± 0.019b 85.40 0.26 ± 0.010b 83.75 0.31 ± 0.016b 83.59
13j 0.32 ± 0.012b 72.64 0.34 ± 0.023b 75.18 0.40 ± 0.013b 75.00 0.49 ± 0.011b 74.07
13k 0.20 ± 0.010b 82.90 0.19 ± 0.016b 86.13 0.25 ± 0.012b 84.37 0.30 ± 0.020b 84.20
13l 0.11 ± 0.019a 90.59 0.09 ± 0.011a 93.43 0.11 ± 0.021a 93.12 0.16 ± 0.012a 91.53
13m 0.27 ± 0.024b 76.92 0.26 ± 0.020b 81.02 0.32 ± 0.011b 80.00 0.42 ± 0.017b 77.77
13n 0.25 ± 0.006b 78.63 0.21 ± 0.012b 84.67 0.27 ± 0.021b 83.12 0.35 ± 0.009b 81.48
13o 0.07 ± 0.011a 94.01 0.05 ± 0.021a 96.35 0.07 ± 0.011a 95.62 0.11 ± 0.014a 94.17
13p 0.36 ± 0.010 69.23 0.40 ± 0.015 70.80 0.47 ± 0.010 70.62 0.52 ± 0.012 72.48
13q 0.38 ± 0.019 67.52 0.45 ± 0.019 67.15 0.26 ± 0.049b 67.50 0.58 ± 0.020 69.31
  1. aP < 0.001 and b P < 0.01. Control (−) (0.1 mL of saline solution)
  2. cValues are expressed as mean ± SEM from six observations and data is analyzed by one way ANOVA followed by Dunnett’s ‘t’ test
  3. dValues in parentheses [percentage anti-inflammatory activity (% AI)]