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Table 1 In vivo anti-inflammatory activity of novel 1,2,3-triazoles (13aq)

From: Synthesis, anti-inflammatory, bactericidal activities and docking studies of novel 1,2,3-triazoles derived from ibuprofen using click chemistry

Compound

3 h

4 h

5 h

6 h

Swelling

Inhibition (%)

Swelling

Inhibition (%)

Swelling

Inhibition (%)

Swelling

Inhibition (%)

Volume of edemac (mL) and % AId

Control (−)

1.17 ± 0.032

 

1.37 ± 0.012

 

1.60 ± 0.019

 

1.89 ± 0.009

 

Ibuprofen

0.08 ± 0.021

93.16

0.06 ± 0.027

95.62

0.07 ± 0.027

95.62

0.10 ± 0.021

94.70

13a

0.60 ± 0.015

48.17

0.60 ± 0.004

56.20

0.66 ± 0.004

58.75

0.71 ± 0.012

62.43

13b

0.62 ± 0.024a

47.00

0.61 ± 0.008a

55.47

0.69 ± 0.008a

56.87

0.74 ± 0.016a

60.84

13c

0.17 ± 0.020

85.47

0.17 ± 0.016

87.59

0.21 ± 0.009

86.87

0.26 ± 0.011

86.24

13d

0.50 ± 0.007

57.26

0.49 ± 0.019

64.23

0.54 ± 0.009

66.25

0.56 ± 0.015

70.37

13e

0.43 ± 0.011

63.24

0.42 ± 0.023

69.34

0.53 ± 0.013

66.87

0.62 ± 0.018

67.19

13f

0.54 ± 0.015

53.84

0.54 ± 0.010

60.58

0.57 ± 0.019

64.37

0.62 ± 0.011

67.19

13g

0.15 ± 0.017a

87.17

0.12 ± 0.007a

91.24

0.15 ± 0.014a

90.62

0.20 ± 0.012a

89.41

13h

0.40 ± 0.022

65.81

0.49 ± 0.012

64.23

0.56 ± 0.017

65.00

0.60 ± 0.011

68.25

13i

0.23 ± 0.009b

80.34

0.20 ± 0.019b

85.40

0.26 ± 0.010b

83.75

0.31 ± 0.016b

83.59

13j

0.32 ± 0.012b

72.64

0.34 ± 0.023b

75.18

0.40 ± 0.013b

75.00

0.49 ± 0.011b

74.07

13k

0.20 ± 0.010b

82.90

0.19 ± 0.016b

86.13

0.25 ± 0.012b

84.37

0.30 ± 0.020b

84.20

13l

0.11 ± 0.019a

90.59

0.09 ± 0.011a

93.43

0.11 ± 0.021a

93.12

0.16 ± 0.012a

91.53

13m

0.27 ± 0.024b

76.92

0.26 ± 0.020b

81.02

0.32 ± 0.011b

80.00

0.42 ± 0.017b

77.77

13n

0.25 ± 0.006b

78.63

0.21 ± 0.012b

84.67

0.27 ± 0.021b

83.12

0.35 ± 0.009b

81.48

13o

0.07 ± 0.011a

94.01

0.05 ± 0.021a

96.35

0.07 ± 0.011a

95.62

0.11 ± 0.014a

94.17

13p

0.36 ± 0.010

69.23

0.40 ± 0.015

70.80

0.47 ± 0.010

70.62

0.52 ± 0.012

72.48

13q

0.38 ± 0.019

67.52

0.45 ± 0.019

67.15

0.26 ± 0.049b

67.50

0.58 ± 0.020

69.31

  1. aP < 0.001 and b P < 0.01. Control (−) (0.1 mL of saline solution)
  2. cValues are expressed as mean ± SEM from six observations and data is analyzed by one way ANOVA followed by Dunnett’s ‘t’ test
  3. dValues in parentheses [percentage anti-inflammatory activity (% AI)]