Table 3 Pharmacodynamic parameters of Rh123 after treated with berberine or verapamil in rats ( \( \overline{\text{x}} \) ± s, n = 8)
From: Effects of berberine on pharmacokinetics of midazolam and rhodamine 123 in rats in vivo
Parameters | Negative control group | BBR 50 mg/kg | BBR 100 mg/kg | BBR 200 mg/kg | Verapamil 4 mg/kg |
|---|---|---|---|---|---|
AUC(0-t) (μg/L h) | 48.36 ± 6.4 | 59.58 ± 13.37 | 77.51 ± 6.84*** | 95.49 ± 15.99*** | 93.01 ± 13.07*** |
AUC(0−∞) (μg/L h) | 50.97 ± 6.99 | 63.52 ± 14.52 | 84.42 ± 7.72*** | 102.8 ± 18.25*** | 105.8 ± 14.79*** |
CLz (L/h/kg) | 99.64 ± 14.01 | 81.95 ± 17.98* | 59.63 ± 5.46*** | 50.11 ± 10.54*** | 47.96 ± 6.41*** |
Vz (L/kg) | 1687 ± 219 | 1446 ± 347 | 1208 ± 293** | 1209 ± 124*** | 1204 ± 205** |
t1/2 (h) | 11.78 ± 0.89 | 12.39 ± 2.9 | 13.97 ± 2.73 | 14.47 ± 1.88 | 17.41 ± 1.79** |
tmax (h) | 1.4 ± 0.96 | 0.4 ± 0.09 | 0.5 ± 0.29 | 0.27 ± 0.15 | 0.4 ± 0.09 |
Cmax (μg/L) | 4.41 ± 0.45 | 10.18 ± 5.59 | 11.78 ± 3.19* | 16. 25 ± 8.65*** | 11.39 ± 2.76* |