Table 2 Dynamic parameters of 1’-hydroxymidazolam after treated with BBR or ketoconazole in rats (\( \overline{\text{x}} \) ± s, n = 8)
From: Effects of berberine on pharmacokinetics of midazolam and rhodamine 123 in rats in vivo
Parameters | negative control group | BBR 50 mg/kg | BBR 100 mg/kg | BBR 200 mg/kg | ketoconazole 75 mg/kg |
|---|---|---|---|---|---|
AUC(0−t) (μg/mL h) | 0.66 ± 0.28 | 0.46 ± 0.19* | 0.42 ± 0.11** | 0.36 ± 0.09*** | 0.37 ± 0.10*** |
AUMC(0−t) (μg/mL h) | 0.68 ± 0.34 | 0.47 ± 0.22* | 0.41 ± 0.12** | 0.37 ± 0.11** | 0.37 ± 0.12** |
CLz (L/h/kg) | 29.93 ± 11.89 | 44.9 ± 20.95* | 45.17 ± 10.85* | 50.99 ± 11.90** | 50.66 ± 12.94*** |
Vz (L/kg) | 41.61 ± 12.07 | 67.57 ± 32.43* | 63.75 ± 18.66* | 71.33 ± 26.01* | 75.57 ± 23.57** |
t1/2 (min) | 61 ± 17 | 62 ± 8 | 58 ± 11 | 57 ± 12 | 61 ± 7 |
tmax (min) | 17 ± 5 | 11 ± 4 | 12 ± 6 | 12 ± 7 | 13 ± 7 |
Cmax (μg/mL) | 0.51 ± 0.16 | 0.44 ± 0.13 | 0.40 ± 0.08* | 0.32 ± 0.07*** | 0.33 ± 0.09** |