Table 1 Dynamic parameters of midazolam after treated with BBR or ketoconazole in rats (\( \overline{\text{x}} \) ± s, n = 8)
From: Effects of berberine on pharmacokinetics of midazolam and rhodamine 123 in rats in vivo
Parameters | Negative control group | BBR 50 mg/kg | BBR 100 mg/kg | BBR 200 mg/kg | Ketoconazole 75 mg/kg |
|---|---|---|---|---|---|
AUC(0−t) (μg/mL h) | 1.25 ± 0.29 | 1.69 ± 0.31 | 2.03 ± 0.44*** | 2.12 ± 0.66*** | 2.47 ± 0.49*** |
AUMC(0−t) (μg/mL h) | 1.24 ± 0.37 | 1.49 ± 0.29 | 1.98 ± 0.56** | 2.08 ± 0.75** | 2.57 ± 0.65*** |
CLz (L/h/kg) | 14.89 ± 4.93 | 11.23 ± 1.8* | 9.19 ± 2.31*** | 9.33 ± 4.09** | 7.17 ± 1.85*** |
Vz (L/kg) | 20.51 ± 3.63 | 12.58 ± 3.05*** | 12.12 ± 3.28*** | 13.05 ± 3.74*** | 10.85 ± 2.37*** |
t1/2 (min) | 61 ± 18 | 47 ± 11 | 56 ± 14 | 61 ± 12 | 66 ± 23 |
tmax (min) | 13 ± 5 | 12 ± 5 | 12 ± 6 | 11 ± 5 | 10 ± 3 |
Cmax (μg/mL) | 1.13 ± 0.25 | 1.69 ± 0.23** | 1.84 ± 0.29*** | 2.12 ± 0.53** | 2.21 ± 0.29*** |