Table 4 Combined genotypic frequency for ApaI, TaqI and BsmI polymorphisms in VDR gene
From: Association of vitamin D receptor variants with clinical parameters in prostate cancer
Genotypes | PCa X BPH | PCa X healthy volunteers | BPH X healthy volunteers | |||
|---|---|---|---|---|---|---|
OR (95 % CI) | P | OR (95 % CI) | P | OR (95 % CI) | P | |
Bsm I - Apa I | ||||||
AATT | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference |
AGTT | 0.66 (0.19–2.24) | 0.71 | 2.57 (1.06–6.26) | 0.06 | 3.90 (1.19–12.84) | 0.04* |
GGGT | 1.88 (0.43–8.22) | 0.64 | 1.13 (0.49–2.61) | 0.95 | 0.60 (0.15–2.45) | 0.72 |
AGGT | 1.13 (0.34–3.79) | 0.91 | 1.41 (0.65–3.04) | 0.49 | 1.25 (0.40–3.91) | 0.93 |
GGGG | 1.17 (0.31–4.42) | 0.92 | 1.53 (0.66–3.57) | 0.44 | 1.30 (0.37–4.60) | 0.93 |
GGTT | ND | ND | 3.54 (1.08–11.57) | 0.07 | ND | ND |
Apa I - Taq I | ||||||
TTTT | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference |
TTTC | 0.69 (0.16–2.97) | 0.89 | 0.85 (0.28–2.56) | 0.99 | 1.22 (0.26–5.68) | 0.90 |
GTTT | 1.71 (0.33–8.93) | 0.85 | 0.44 (0.15–1.30) | 0.22 | 0.26 (0.05–1.42) | 0.26 |
GTTC | 0.77 (0.18–3.25) | 1.00 | 0.41 (0.14–1.16) | 0.15 | 0.53 (0.12–2.35) | 0.67 |
TTCC | 0.68 (0.12–3.83) | 1.00 | 0.28 (0.08–0.92) | 0.07 | 0.41 (0.07–2.27) | 0.57 |
GGTT | 1.09 (0.23–5.19) | 0.77 | 0.55 (0.18–1.63) | 0.41 | 0.50 (0.10–2.51) | 0.69 |
Bsm I - Taq I | ||||||
GGTT | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference |
AGTC | 0.45 (0.20–1.06) | 0.10 | 1.07 (0.64–1.82) | 0.89 | 2.37 (1.05–5.38) | 0.06 |
AATC | ND | ND | 1.15 (0.33–3.97) | 0.92 | ND | ND |
AACC | 0.47 (0.12–1.83) | 0.47 | 0.56 (0.24–1.33) | 0.27 | 1.20 (0.34–4.21) | 0.96 |
AGTT | 1.25 (0.24–6.48) | 0.89 | 3.30 (1.09–10.00) | 0.05* | 2.64 (0.45–15.49) | 0.58 |
GGTC | ND | ND | 1.93 (0.58–6.53) | 0.44 | ND | ND |
AGCC | ND | ND | 1.38 (0.08–22.54) | 0.62 | ND | ND |
HAPLOTYPES | ||||||
Bsm I - Apa I | ||||||
AT | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference |
GT | 1.28 (0.71–2.32) | 0.51 | 1.08 (0.72–1.62) | 0.78 | 0.85 (0.48–1.51) | 0.67 |
GG | 1.43 (0.76–2.66) | 0.34 | 0.92 (0.61–1.38) | 0.75 | 0.64 (0.35–1.18) | 0.20 |
AG | 1.29 (0.59–2.78) | 0.66 | 0.95 (0.57–1.58) | 0.94 | 0.74 (0.35–1.56) | 0.54 |
Apa I - Taq I | ||||||
TT | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference |
TC | 0.82 (0.45–1.49) | 0.61 | 0.89 (0.59–1.33) | 0.63 | 1.09 (0.61–1.95) | 0.90 |
GT | 1.16 (0.62–2.15) | 0.77 | 0.84 (0.57–1.24) | 0.43 | 0.73 (0.40–1.33) | 0.38 |
GC | 0.80 (0.38–1.71) | 0.71 | 0.75 (0.45 to1.25) | 0.33 | 0.94 (0.45–1.94) | 0.99 |
Bsm I - Taq I | ||||||
AT | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference |
GC | 0.94 (0.49–1.81) | 0.98 | 0.93 (0.57–1.50) | 0.85 | 1.0 (0.52–1.88) | 0.90 |
GT | 1.30 (0.72–2.34) | 0.48 | 0.94 (0.62–1.41) | 0.83 | 0.72 (0.40–1.29) | 0.34 |
AC | 0.93 (0.49–1.77) | 0.96 | 0.78 (0.50–1.24) | 0.35 | 0.84 (0.45–1.56) | 0.69 |