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Table 2 Genotypic and allelic frequencies for VDR gene polymorphisms and clinical parameters of patients with prostate cancer, benign prostatic hyperplasia and healthy volunteers

From: Association of vitamin D receptor variants with clinical parameters in prostate cancer

SNP

PCa (N = 132)

BPH (N = 41)

Healthy volunteers (N = 169)

N (%)

Age*

PSA*

N (%)

Age*

PSA*

N (%)

Age*

FokI

        

 CC

54.00 (40.91)

65.08 (8.79)

14.08 (18.35)

18.00 (43.90)

66.25 (10.67)

18.30 (46.56)

79.00 (46.75)

23.00 (4.57)

 CT

62.00 (46.97)

67.51 (8.41)

19.21 (32.75)

19.00 (46.34)

70.00 (10.59)

12.75 (16.73)

76.00 (44.97)

22.98 (4.31)

 TT

16.00 (12.12)

65.53 (11.29)

50.68 (123.35)

4.00 (9.76)

72.33 (5.77)

8.27 (2.22)

14.00 (8.38)

22.86 (6.18)

Alleles C/T

170/94 (64.39/35.61)

  

55/27 (67.07/32.93)

  

234/104 (69.23/30.77)

 

§PHWE

0.78

  

0.75

  

0.47

 

2

PCa x BPH = 0.90

  

PCa x Healthy = 0.42

  

BPH x Healthy = 0.93

 

BsmI

        

 AA

14.00 (10.61)

64.31 (9.66)

30.11 (57.48)

5.00 (12.20)

71.00 (8.21)

3.53 (2.40)

28.00 (16.57)

23.37 (4.50)

 AG

63.00 (47.73)

67.69 (8.24)

17.09 (22.57)

25.00 (60.98)

66.80 (11.25)

10.41 (14.68)

70.00 (41.42)

22.93 (4.78)

 GG

55.00 (41.67)

65.31 (9.44)

21.49 (61.54)

11.00 (26.86)

71.45 (8.71)

26.14 (55.23)

71.00 (42.01)

22.91 (4.15)

Alleles A/G

91/173 (34.47/65.53)

  

35/47 (42.68/57.32)

  

126/212 (37.28/62.72)

 

§PHWE

0.52

  

0.11

  

0.14

 

2

PCa x BPH = 0.23

  

PCa x Healthy = 0.28

  

BPH x Healthy = 0.08

 

ApaI

        

 TT

49.00 (37.12)

65.74 (9.22)

19.98 (36.07)

18.00 (43.90)

66.56 (10.78)

9.72 (17.38)

51.00 (30.18)

22.36 (4.94)

 TG

59.00 (44.70)

65.44 (9.29)

25.48 (63.84)

16.00 (39.02)

69.57 (10.50)

8.45 (6.10)

89.00 (52.66)

22.91 (4.33)

 GG

24.00 (18.18)

69.30 (7.18)

10.66 (12.26)

7.00 (17.07)

71.14 (9.23)

37.11 (68.48)

29.00 (17.16)

24.77 (3.94)

 Alleles T/G

157/107 (59.47/40.53)

  

52/30 (63.41/36.59)

  

191/147 (56.51/43,49)

 

§PHWE

0.40

  

0.31

  

0.35

 

2

PCa x BPH = 0.73

  

PCa x Healthy = 0.35

  

BPH x Healthy = 0.21

 

TaqI

        

 TT

60.00 (45.45)

66.09 (8.94)

20.77 (60.47)

13.00 (31.71)

70.75 (8.66)

23.79 (53.24)

71.00 (42.01)

23.33 (4.01)

 TC

62.00 (46.97)

66.93 (8.92)

17.59 (21.26)

23.00 (56.10)

66.38 (11.44)

10.69 (15.05)

75.00 (44.38)

22.90 (5.00)

 CC

10.00 (7.58)

63.25 (9.78)

37.62 (72.71)

5.00 (12.20)

73.50 (6.24)

6.03 (2.65)

23.00 (13.61)

22.40 (4.47)

 Alleles T/C

182/82 (68.94/31.06)

  

49/33 (59.76/40.24)

  

217/121 (64.20/35.80)

 

§PHWE

0.27

  

0.29

  

0.65

 

2

PCa x BPH = 0.26

  

PCa x Healthy = 0.25

  

BPH x Healthy = 0.39

 
  1. 2: P value of Chi square test
  2. SNP single nucleotide polymorphism
  3. * Mean (±SD)
  4. §PHWE: Hardy–Weinberg equilibrium