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Table 4 Effects of active components of Radix Scrophulariae (ACRS) on mRNA expression of collagen types I and III, angiotensin converting enzyme (ACE) and transforming growth factor-β1 (TGF-β1) in spontaneously hypertensive rats (SHR) and Wistar–Kyoto rats (WKY) (\(\bar{x}\) ± SE, n = 6)

From: Active components from Radix Scrophulariae inhibits the ventricular remodeling induced by hypertension in rats

Group

Collage I mRNA

Collage III mRNA

TGF-β1 mRNA

ACE mRNA

WKY control

1.03 ± 0.59

1.29 ± 0.86

0.62 ± 0.37

1.20 ± 0.59

WKY+ 140 mg/kg ACRS 

1.47 ± 0.60

1.28 ± 0.85

0.85 ± 0.27

1.30 ± 0.42

SHR control

4.85 ± 2.60††

1.47 ± 0.68

1.58 ± 1.05

5.51 ± 3.83

SHR+ 40 mg/kg captopril

1.17 ± 0.28**

0.79 ± 0.34

0.77 ± 0.18*

1.35 ± 0.24*

SHR+ 70 mg/kg ACRS

1.39 ± 0.44**

1.32 ± 0.44

0.94 ± 0.22*

1.21 ± 0.23*

SHR+ 140 mg/kg ACRS

1.22 ± 0.51**

1.15 ± 0.51

0.60 ± 0.34*

1.25 ± 0.24*

SHR+ 280 mg/kg ACRS

1.22 ± 0.49**

1.08 ± 0.60

0.88 ± 0.18*

1.07 ± 0.20*

  1. Values are expressed as the relative integrated intensity, and normalized to that of the GAPDH. Compared with WKY control group: †† P < 0.01; compared with SHR control group: * P < 0.05; ** P < 0.01