Group | Collage I mRNA | Collage III mRNA | TGF-β1 mRNA | ACE mRNA |
---|---|---|---|---|
WKY control | 1.03 ± 0.59 | 1.29 ± 0.86 | 0.62 ± 0.37 | 1.20 ± 0.59 |
WKY+ 140 mg/kg ACRS | 1.47 ± 0.60 | 1.28 ± 0.85 | 0.85 ± 0.27 | 1.30 ± 0.42 |
SHR control | 4.85 ± 2.60†† | 1.47 ± 0.68 | 1.58 ± 1.05† | 5.51 ± 3.83† |
SHR+ 40 mg/kg captopril | 1.17 ± 0.28** | 0.79 ± 0.34 | 0.77 ± 0.18* | 1.35 ± 0.24* |
SHR+ 70 mg/kg ACRS | 1.39 ± 0.44** | 1.32 ± 0.44 | 0.94 ± 0.22* | 1.21 ± 0.23* |
SHR+ 140 mg/kg ACRS | 1.22 ± 0.51** | 1.15 ± 0.51 | 0.60 ± 0.34* | 1.25 ± 0.24* |
SHR+ 280 mg/kg ACRS | 1.22 ± 0.49** | 1.08 ± 0.60 | 0.88 ± 0.18* | 1.07 ± 0.20* |