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Table 3 Effects of active components of Radix Scrophulariae (ACRS) on serum concentration of norepinephrine (NE), myocardium Angiotensin II and serum level of tumor necrosis factor α (TNF-α) concentration in spontaneously hypertensive rats (SHR) and Wistar–Kyoto rats (WKY) (\(\bar{x}\)  ± SE, n = 6)

From: Active components from Radix Scrophulariae inhibits the ventricular remodeling induced by hypertension in rats

Group

NE (ng/ml)

Ang II (pg/mg·prot)

TNF-α (ng/L)

WKY control

0.15 ± 0.03

89.61 ± 29.51

24.95 ± 1.26

WKY+ 140 mg/kg ACRS

0.14 ± 0.01

62.75 ± 13.56

24.53 ± 0.92

SHR control

0.36 ± 0.20†

195.23 ± 113.35†

27.63 ± 1.96†

SHR+ 40 mg/kg captopril

0.16 ± 0.02*

91.07 ± 8.28*

24.11 ± 1.11*

SHR+ 70 mg/kg ACRS

0.37 ± 0.15

94.43 ± 58.96

22.89 ± 2.33**

SHR+ 140 mg/kg ACRS

0.15 ± 0.02*

71.86 ± 14.41*

24.08 ± 2.36*

SHR+ 280 mg/kg ACRS

0.18 ± 0.05*

72.79 ± 20.81*

23.04 ± 3.69*

  1. Compared with WKY control group: † P < 0.05; compared with SHR control group: * P < 0.05; ** P < 0.01
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