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Table 2 Effects of active components of Radix Scrophulariae (ACRS) on interstitial collagen volume fraction (ICVF), perivascular collagen area to luminal area ratio (PVCA), collagen types I and III volume fraction of the left ventricle in spontaneously hypertensive rats (SHR) and Wistar–Kyoto rats (WKY) (\(\bar{x}\) ± SE, n = 6)

From: Active components from Radix Scrophulariae inhibits the ventricular remodeling induced by hypertension in rats

Group

ICVF (%)

PVCA (ratio)

Collage I (%)

Collage III (%)

I/III

WKY control

6.53 ± 4.10

0.78 ± 0.33

0.22 ± 0.20

0.06 ± 0.04

3.56 ± 2.24

WKY+ 140 mg/kg ACRS

4.29 ± 2.71

1.01 ± 0.66

0.26 ± 0.20

0.11 ± 0.07

2.89 ± 2.30

SHR control

22.55 ± 5.88††

10.36 ± 4.38††

7.78 ± 2.06††

0.49 ± 0.44

33.58 ± 26.93

SHR+ 40 mg/kg captopril

5.72 ± 4.08**

0.92 ± 0.37**

0.15 ± 0.10**

0.11 ± 0.05

2.76 ± 3.90*

SHR+ 70 mg/kg ACRS

7.51 ± 3.35**

1.59 ± 0.52**

0.42 ± 0.31**

0.13 ± 0.04

3.97 ± 4.18*

SHR+ 140 mg/kg ACRS

6.54 ± 2.08**

0.76 ± 0.42**

0.38 ± 0.31**

0.08 ± 0.05*

6.54 ± 7.79*

SHR+ 280 mg/kg ACRS

10.23 ± 7.20**

1.21 ± 0.75**

0.48 ± 0.65**

0.07 ± 0.06*

7.38 ± 10.37*

  1. Compared with WKY control group: †† P < 0.01; compared with SHR control group: * P < 0.05; ** P < 0.01