Table 1 Characteristics of the patients according to accomplished first-line treatment
Characteristics | All | Elidible to initial HD-MTX | Non-eligible | ||
|---|---|---|---|---|---|
HDC-ASCT | HD-MTX consolidation | HD-MTX + WBR | WBR alone or palliation | ||
Total number | 61 | 10 | 16 | 23 | 9 |
Gender (man:woman) | 38:23 | 8:2 | 9:7 | 14:9 | 5:4 |
Age (years) median (range) | 69 (42–80) | 57 (46–62) | 72 (55–80) | 66 (42–79) | 74 (70–79) |
KPS (%) median (range) | 60 (30–100) | 60 (40–90) | 60 (40–90) | 50 (30–100) | 30 (30–40) |
MSKCC | |||||
Class I | 3 | 2 | 0 | 1 | 0 |
Class II | 20 | 4 | 8 | 7 | 0 |
Class III | 38 | 4 | 8 | 15 | 9 |
IELSG score | |||||
0 & 1 | 11 | 3 | 4 | 4 | 0 |
2 & 3 | 32 | 6 | 10 | 12 | 1 |
4 & 5 | 18 | 1 | 2 | 7 | 1 |
Response to HD-MTX | |||||
CR | 30 | 10 | 16 | 4 | – |
PR | 7 | 0 | 0 | 7 | – |
PD | 12 | 0 | 0 | 12 | – |
WBR number | 29 | 0 | 0 | 23 | 6 |
Median dose (range) | 50 (30–59.4) | – | – | 50 (40–59.4) | 40 (30–50) |