Fig. 3

Preventive administration of crizotinib prior to tumor onset did not alter tumor parameters. Diet was started at 8 weeks of age (baseline). a Body composition was measured by MRI (LFD vs. HFD *P < 0.0001). b Gonadal fat pad mass was determined at sacrifice (LFD vs. HFD *P < 0.0001). c Upon initiation of crizotinib treatment (50 mg/kg by oral gavage) at 9 weeks of age, mice were palpated twice weekly for tumor onset. Median tumor latency did not differ with diet or treatment (LFD veh-treated median 15.0 weeks, N = 22; LFD criz-treated median 16.1 weeks, N = 21; HFD veh-treated median 16.0 weeks; HFD criz-treated median 16.2 weeks). d Total tumor burden was assessed at sacrifice