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Table 3 Arrhythmic effects of sotalol, quinidine, and E-4031 observed during the field potential (FP) recordings

From: Effects of cardioactive drugs on human induced pluripotent stem cell derived long QT syndrome cardiomyocytes

Sotalol (µM) hESC (n = 11) WTa (n = 6) WTb (n = 12) LQT1A (n = 13)*,s LQT1B (n = 13)*,a LQT2 (n = 15)a
0.8       
1.6       
5.7       AD(2)
9.7 AD(4)   AD(1)    
19.4   AD(1)   AD(2)   
Quinidine (µM) hESC (n = 10) WTa (n = 6) WTb (n = 11) LQT1A (n = 12)*,s LQT1B (n = 16)*,a LQT2 (n = 12)a
1.5       
3       AD(1)
9 AD(3)   BA(7) AD(1) BA(5) BA(5)
15   BA(2)   BA(2)   
30 BA(1)      
E-4031 (nM) hESC (n = 10) WTa (n = 6) WTb (n = 8) LQT1A (n = 16)*,s LQT1B (n = 16)*,a LQT2 (n = 13)a
10       
100       BA(4)
300 AD(7) AD(2)   AD(8)   AD(3)
500 BA(1) BA(2) BA(1)   AD(4)  
700      BA(1)  
  1. The reported values in the table are the lowest concentrations that induced the effect. The numbers in parentheses indicate how many cardiomyocyte clusters in total were affected
  2. AD afterdepolarization (AD)-waveforms, BA beating arrest (termination of FP activity)
  3. * Siblings s symptomatic a asymptomatic