Association between OGG1 Ser326Cys polymorphism and risk of upper aero-digestive tract and gastrointestinal cancers: a meta-analysis

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Table 2 Pooled OR of the OGG1 Ser326Cys polymorphism based on ethnicity, sample size and cancer type

Variables	No. of studies	Case/control	Dominant model		Recessive model		Homozygous model
Variables	No. of studies	Case/control	OR (95 % CI)	P^a	OR (95 % CI)	P^a	OR (95 % CI)	P^a
Ethnicity
Asian	6	1161/1407	1.21 (0.93–1.56)	0.15	1.40 (1.09–1.80)	0.009*	1.56 (1.15–2.11)	0.004*
Caucasian	11	4372/5427	1.22 (1.01–1.48)	0.03*	1.29 (0.95–1.76)	0.104	1.40 (0.97–2.03)	0.07
Sample size
<500	8	943/1474	1.31 (0.93–1.85)	0.122	1.64 (1.14–2.35)	0.007*	1.83 (1.01–3.29)	0.044*
≥500	9	4590/5360	1.16 (0.99–1.35)	0.06	1.23 (1.05–1.44)	0.012*	1.32 (0.99–1.76)	0.06
Cancer type
GI	11	4054/5245	1.17 (0.97–1.40)	0.09	1.28 (0.95–1.74)	0.103	1.36 (0.96–1.92)	0.08
UADT	6	1479/1589	1.32 (1–1.74)	<0.05*	1.37 (1.09–1.73)	<0.05*	1.74 (1.08–2.80)	0.02*