Fig. 6From: Ethyl pyruvate attenuated coxsackievirus B3-induced acute viral myocarditis by suppression of HMGB1/RAGE/NF-ΚB pathwayEffect of ethyl pyruvate (EP) on the cytokines. The sham mice and AVMC mice were intraperitoneally administrated with Ringer’s lactate solution (RLS) or 80 mg/kg/day EP from the 5th day to the 7th day after CVB3 infection. a–d Real-time PCR was used for analysis on the expression of TNF-α (a), IL-1β (b), IL-17 (c) and IL-10 (d) in the hearts. Data were shown as mean ± SE from 6 to 12 individual experiments. *P < 0.001 versus Sham + RLS; # P < 0.001 versus Sham + EP; $ P < 0.01 versus AVMC + RLS. e–h ELISA for quantitative analysis of serum TNF-α, IL-1β, IL-17 and IL-10. Data were shown as mean ± SE from 6 to 12 individual experiments. *P < 0.001 versus Sham + RLS; # P < 0.001 versus Sham + EP; $ P < 0.01 versus AVMC + RLSBack to article page