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Table 2 Overall response rate

From: A phase II, multicenter, single-arm trial of eribulin as first-line chemotherapy for HER2-negative locally advanced or metastatic breast cancer

n (%)

Overall

Neoadjuvant/adjuvant chemotherapy

Subtype

Visceral metastasis

Disease free interval

Yes

No

With A/T

W/O A/T

Luminal

TN

Yes

No

<2 yr

≥2 yr

W/O Op.

Patients

35 (100)

15 (42.9)

20 (57.1)

10 (28.6)

25 (71.4)

28 (80.0)

7 (20.0)

23 (65.7)

12 (34.3)

7 (20.0)

14 (40.0)

14 (40.0)

CR

2 (5.7)

1 (6.7)

1 (5.0)

0 (0.0)

2 (8.0)

2 (7.1)

0 (0.0)

1 (4.3)

1 (8.3)

0 (0.0)

1 (7.1)

1 (7.1)

PR

17 (48.6)

4 (26.7)

13 (65.0)

3 (30.0)

14 (56.0)

13 (46.4)

4 (57.1)

10 (43.5)

7 (58.3)

3 (42.9)

5 (35.7)

9 (64.3)

SD ≥ 24 w

3 (8.6)

2 (13.3)

2 (10.0)

1 (10.0)

3 (12.0)

3 (10.7)

1 (14.3)

3 (13.0)

1 (8.3)

2 (28.6)

1 (7.1)

1 (7.1)

SD < 24 w

8 (22.9)

5 (33.3)

2 (10.0)

4 (40.0)

3 (12.0)

5 (17.9)

2 (28.6)

4 (17.4)

3 (25.0)

1 (14.3)

5 (35.7)

1 (7.1)

PD

2 (5.7)

1 (6.7)

1 (5.0)

0 (0.0)

2 (8.0)

2 (7.1)

0 (0.0)

2 (8.7)

0 (0.0)

0 (0.0)

1 (7.1)

1 (7.1)

NE

3 (8.6)

2 (13.3)

1 (5.0)

2 (20.0)

1 (4.0)

3 (10.7)

0 (0.0)

3 (13.0)

0 (0.0)

1 (14.3)

1 (7.1)

1 (7.1)

ORR

19 (54.3)

5 (33.3)

14 (70.0)

3 (30.0)

16 (64.0)

15 (53.6)

4 (57.1)

11 (47.8)

8 (66.7)

3 (42.9)

6 (42.9)

10 (71.4)

CBR

22 (62.9)

7 (46.7)

16 (80.0)

4 (40.0)

19 (76.0)

18 (64.3)

5 (71.4)

14 (60.9)

9 (75.0)

5 (71.4)

7 (50.0)

11 (78.6)

  1. CR complete response, PR partial response, SD stable disease, PD progressive disease, NE not evaluable, ORR overall response rate, CBR clinical benefit rate, A/T anthracycline- or taxane-based regimens, W/O without, TN triple negative, yr years, Op operation