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Table 3 Special categories of patients recommended for exclusion from the compulsory generic substitution (Lamy 1986; Krämer et al. 2007; Crawford et al. 2006)

From: Potential problems and recommendations regarding substitution of generic antiepileptic drugs: a systematic review of literature

Special categories Examples
High risk patients Extreme age groups, pregnant women, patients with multiple disorders being treated with several drugs, solitary individual, etc.
High risk diseases Chronic diseases, diseases aggravated after the administration of drugs prescribed for co-morbid condition, etc.
High risk drugs Narrow therapeutic index drugs, drugs requiring individualization of dose, drugs exhibiting severe drug–drug interactions, drugs with the complex therapeutic regimen, drugs initiating the prescribing cascade, etc.