AEDs | Potential problems | References |
---|---|---|
Carbamazepine | Increased breakthrough seizures with generic substitution | Sachdeo and Belendiuk (1987), Welty et al. (1992), Koch and Allen (1987), Hartley et al. (1991), Berg et al. (2008), Hartley et al. (1990) |
Failure of drug therapy with generic substitution | ||
Toxicity and increased serum levels with generic substitution | Gilman et al. (1993), Jumao-as et al. (1989), Reunanen et al. (1992) | |
Adverse effects with generics | Neuvonen (1985), Hartley et al. (1990), Olling et al. (1999), Garnett et al. (2005) | |
Phenytoin | Increased breakthrough seizures with generic substitution | Yamada and Welty (Yamada and Welty 2011), Berg et al. (2008) |
Toxicity and increased serum levels with generic substitution | Soryal and Richens (1992) | |
Adverse effects with generics | Chen et al. (1982) | |
Valproate | Increased breakthrough seizures with generic substitution | Berg et al. (2008) |
Failure of drug therapy | ||
Toxicity and increased serum levels with generic substitution | Levine et al. (2000) | |
Adverse effects with generics | Margolese et al. (2010), Sherwood et al. (1998), Wassef et al. (2005), Zarate et al. (1999), Schwartz et al. (2000) | |
Leviteracetam | Increased breakthrough seizures with generic substitution | Armstrong et al. (2010), Fitzgerald and Jacobson (2011), Chaluvadi et al. (2011) |
Adverse effects with generics | (Chaluvadi et al. 2011) | |
Topiramate | Increased breakthrough seizures with generic substitution | Duh et al. (2009b) |
Adverse effects with generics | Pineyro-Lopez et al. (2009) | |
Gabapentin | Increased breakthrough seizures with generic substitution | Berg et al. (2008) |
Phenobarbital | Failure of drug therapy | Bankstahl et al. (2013) |
Oxcarbazepine | Increased breakthrough seizures with generic substitution | Cook et al. (2009) |
Lamotrigine | Increased breakthrough seizures with generic substitution | |
Toxicity and increased serum levels with generic substitution | Srichaiya et al. (2008), Sabroe and Sabers (2008), Nielsen et al. (2008) | |
Adverse effects with generics | ||
Primidone | Increased breakthrough seizures with generic substitution | Wyllie et al. (1987) |
Zonisamide | Increased breakthrough seizures with generic substitution | Berg et al. (2008) |