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Table 1 Potential problems reported with generic substitution of AEDs

From: Potential problems and recommendations regarding substitution of generic antiepileptic drugs: a systematic review of literature

AEDs Potential problems References
Carbamazepine Increased breakthrough seizures with generic substitution Sachdeo and Belendiuk (1987), Welty et al. (1992), Koch and Allen (1987), Hartley et al. (1991), Berg et al. (2008), Hartley et al. (1990)
Failure of drug therapy with generic substitution Meyer et al. (1992), Welty et al. (1992), Jain (1993)
Toxicity and increased serum levels with generic substitution Gilman et al. (1993), Jumao-as et al. (1989), Reunanen et al. (1992)
Adverse effects with generics Neuvonen (1985), Hartley et al. (1990), Olling et al. (1999), Garnett et al. (2005)
Phenytoin Increased breakthrough seizures with generic substitution Yamada and Welty (Yamada and Welty 2011), Berg et al. (2008)
Toxicity and increased serum levels with generic substitution Soryal and Richens (1992)
Adverse effects with generics Chen et al. (1982)
Valproate Increased breakthrough seizures with generic substitution Berg et al. (2008)
Failure of drug therapy Margolese et al. (2010), Sherr and Kelly (1998)
Toxicity and increased serum levels with generic substitution Levine et al. (2000)
Adverse effects with generics Margolese et al. (2010), Sherwood et al. (1998), Wassef et al. (2005), Zarate et al. (1999), Schwartz et al. (2000)
Leviteracetam Increased breakthrough seizures with generic substitution Armstrong et al. (2010), Fitzgerald and Jacobson (2011), Chaluvadi et al. (2011)
Adverse effects with generics (Chaluvadi et al. 2011)
Topiramate Increased breakthrough seizures with generic substitution Duh et al. (2009b)
Adverse effects with generics Pineyro-Lopez et al. (2009)
Gabapentin Increased breakthrough seizures with generic substitution Berg et al. (2008)
Phenobarbital Failure of drug therapy Bankstahl et al. (2013)
Oxcarbazepine Increased breakthrough seizures with generic substitution Cook et al. (2009)
Lamotrigine Increased breakthrough seizures with generic substitution Makus and McCormick (2007), Nielsen et al. (2008)
Toxicity and increased serum levels with generic substitution Srichaiya et al. (2008), Sabroe and Sabers (2008), Nielsen et al. (2008)
Adverse effects with generics Andermann et al. (2007), Makus and McCormick (2007)
Primidone Increased breakthrough seizures with generic substitution Wyllie et al. (1987)
Zonisamide Increased breakthrough seizures with generic substitution Berg et al. (2008)