TY - JOUR AU - Alikhan, R. AU - Peters, F. AU - Wilmott, R. AU - Cohen, A. T. PY - 2004 DA - 2004// TI - Fatal pulmonary embolism in hospitalised patients: a necropsy review JO - J Clin Pathol VL - 57 UR - https://doi.org/10.1136/jcp.2003.013581 DO - 10.1136/jcp.2003.013581 ID - Alikhan2004 ER - TY - JOUR AU - Barrett, J. C. AU - Fry, B. AU - Maller, J. AU - Daly, M. J. PY - 2005 DA - 2005// TI - Haploview: analysis and visualization of LD and haplotype maps JO - Bioinformatics VL - 21 UR - https://doi.org/10.1093/bioinformatics/bth457 DO - 10.1093/bioinformatics/bth457 ID - Barrett2005 ER - TY - JOUR AU - Beckman, M. G. AU - Hooper, W. C. AU - Critchley, S. E. AU - Ortel, T. L. PY - 2010 DA - 2010// TI - Venous thromboembolism: a public health concern JO - Am J Prev Med VL - 38 UR - https://doi.org/10.1016/j.amepre.2009.12.017 DO - 10.1016/j.amepre.2009.12.017 ID - Beckman2010 ER - TY - JOUR AU - Bertina, R. M. AU - Koeleman, B. P. AU - Koster, T. AU - Rosendaal, F. R. AU - Dirven, R. J. AU - Ronde, H. AU - Velden, P. A. AU - Reitsma, P. H. PY - 1994 DA - 1994// TI - Mutation in blood coagulation factor V associated with resistance to activated protein C JO - Nature VL - 369 UR - https://doi.org/10.1038/369064a0 DO - 10.1038/369064a0 ID - Bertina1994 ER - TY - JOUR AU - Chen, Q. X. AU - Wu, S. J. AU - Wang, H. H. AU - Lv, C. AU - Cheng, B. L. AU - Xie, G. H. AU - Fang, X. M. PY - 2008 DA - 2008// TI - Protein C -1641A/-1654C haplotype is associated with organ dysfunction and the fatal outcome of severe sepsis in Chinese Han population JO - Hum Genet VL - 123 UR - https://doi.org/10.1007/s00439-008-0476-x DO - 10.1007/s00439-008-0476-x ID - Chen2008 ER - TY - JOUR AU - Cohen, A. T. AU - Tapson, V. F. AU - Bergmann, J. F. AU - Goldhaber, S. Z. AU - Kakkar, A. K. AU - Deslandes, B. AU - Huang, W. AU - Zayaruzny, M. AU - Emery, L. AU - Anderson, F. A. PY - 2008 DA - 2008// TI - Venous thromboembolism risk and prophylaxis in the acute hospital care setting (ENDORSE study): a multinational cross-sectional study JO - Lancet VL - 371 UR - https://doi.org/10.1016/S0140-6736(08)60202-0 DO - 10.1016/S0140-6736(08)60202-0 ID - Cohen2008 ER - TY - JOUR AU - Corral, J. AU - Hernandez-Espinosa, D. AU - Soria, J. M. AU - Gonzalez-Conejero, R. AU - Ordonez, A. AU - Gonzalez-Porras, J. R. AU - Perez-Ceballos, E. AU - Lecumberri, R. AU - Sanchez, I. AU - Roldan, V. AU - Mateo, J. AU - Minano, A. AU - Gonzalez, M. AU - Alberca, I. AU - Fontcuberta, J. AU - Vicente, V. PY - 2007 DA - 2007// TI - Antithrombin Cambridge II (A384S): an underestimated genetic risk factor for venous thrombosis JO - Blood VL - 109 UR - https://doi.org/10.1182/blood-2006-08-040774 DO - 10.1182/blood-2006-08-040774 ID - Corral2007 ER - TY - JOUR AU - Cramer, T. J. AU - Gale, A. J. PY - 2011 DA - 2011// TI - Function of the activated protein C (APC) autolysis loop in activated FVIII inactivation JO - Br J Haematol VL - 153 UR - https://doi.org/10.1111/j.1365-2141.2011.08657.x DO - 10.1111/j.1365-2141.2011.08657.x ID - Cramer2011 ER - TY - JOUR AU - D’Ursi, P. AU - Marino, F. AU - Caprera, A. AU - Milanesi, L. AU - Faioni, E. M. AU - Rovida, E. PY - 2007 DA - 2007// TI - ProCMD: a database and 3D web resource for protein C mutants JO - BMC Bioinform VL - 8 UR - https://doi.org/10.1186/1471-2105-8-S1-S11 DO - 10.1186/1471-2105-8-S1-S11 ID - D’Ursi2007 ER - TY - JOUR AU - Dahlbäck, B. AU - Carlsson, M. AU - Svensson, P. J. PY - 1993 DA - 1993// TI - Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C JO - Proc Natl Acad Sci USA VL - 90 UR - https://doi.org/10.1073/pnas.90.3.1004 DO - 10.1073/pnas.90.3.1004 ID - Dahlbäck1993 ER - TY - JOUR AU - Fisher, C. L. AU - Greengard, J. S. AU - Griffin, J. H. PY - 1994 DA - 1994// TI - Models of the serine protease domain of the human antithrombotic plasma factor activated protein C and its zymogen JO - Protein Sci VL - 3 UR - https://doi.org/10.1002/pro.5560030407 DO - 10.1002/pro.5560030407 ID - Fisher1994 ER - TY - STD TI - Gabriel S, Ziaugra L, Tabbaa D (2009) SNP genotyping using the Sequenom MassARRAY iPLEX platform. Curr Protoc Hum Genet Chapter 2: Unit 2.12. doi:10.1002/0471142905.hg0212s60 ID - ref12 ER - TY - JOUR AU - Gandrille, S. AU - Greengard, J. S. AU - Alhenc-Gelas, M. AU - Juhan-Vague, I. AU - Abgrall, J. F. AU - Jude, B. AU - Griffin, J. H. AU - Aiach, M. PY - 1995 DA - 1995// TI - Incidence of activated protein C resistance caused by the ARG 506 GLN mutation in factor V in 113 unrelated symptomatic protein C-deficient patients, The French Network on the behalf of INSERM JO - Blood VL - 86 ID - Gandrille1995 ER - TY - JOUR AU - Goldhaber, S. Z. PY - 2012 DA - 2012// TI - Venous thromboembolism: epidemiology and magnitude of the problem JO - Best Pract Res Clin Haematol VL - 25 UR - https://doi.org/10.1016/j.beha.2012.06.007 DO - 10.1016/j.beha.2012.06.007 ID - Goldhaber2012 ER - TY - JOUR AU - Goldhaber, S. Z. AU - Bounameaux, H. PY - 2012 DA - 2012// TI - Pulmonary embolism and deep vein thrombosis JO - Lancet VL - 379 UR - https://doi.org/10.1016/S0140-6736(11)61904-1 DO - 10.1016/S0140-6736(11)61904-1 ID - Goldhaber2012 ER - TY - JOUR AU - Koster, T. AU - Rosendaal, F. R. AU - Ronde, H. AU - Briët, E. AU - Vandenbroucke, J. P. AU - Bertina, R. M. PY - 1993 DA - 1993// TI - Venous thrombosis due to poor anticoagulant response to activated protein C: leiden Thrombophilia Study JO - Lancet VL - 342 UR - https://doi.org/10.1016/S0140-6736(05)80081-9 DO - 10.1016/S0140-6736(05)80081-9 ID - Koster1993 ER - TY - JOUR AU - Laack, T. A. AU - Goyal, D. G. PY - 2004 DA - 2004// TI - Pulmonary embolism: an unsuspected killer JO - Emerg Med Clin North Am VL - 22 UR - https://doi.org/10.1016/j.emc.2004.05.011 DO - 10.1016/j.emc.2004.05.011 ID - Laack2004 ER - TY - JOUR AU - Lu, X. AU - Tang, L. AU - Xu, K. AU - Ma, J. AU - Guo, T. AU - Mei, H. AU - Yang, R. AU - Yu, J. AU - Wang, Q. AU - Yang, Y. AU - Jian, X. AU - Hu, Y. PY - 2013 DA - 2013// TI - Novel association of a PROC variant with ischemic stroke in a Chinese Han population JO - Hum Genet VL - 132 UR - https://doi.org/10.1007/s00439-012-1225-8 DO - 10.1007/s00439-012-1225-8 ID - Lu2013 ER - TY - JOUR AU - Mesters, R. M. AU - Heeb, M. J. AU - Griffin, J. H. PY - 1993 DA - 1993// TI - A novel exosite in the light chain of human activated protein C essential for interaction with blood coagulation factor Va JO - Biochemistry VL - 32 UR - https://doi.org/10.1021/bi00210a014 DO - 10.1021/bi00210a014 ID - Mesters1993 ER - TY - JOUR AU - Miyata, T. AU - Sakata, T. AU - Yasumuro, Y. AU - Okamura, T. AU - Katsumi, A. AU - Saito, H. AU - Abe, T. AU - Shirahata, A. AU - Sakai, M. AU - Kato, H. PY - 1998 DA - 1998// TI - Genetic analysis of protein C deficiency in nineteen Japanese families: five recurrent defects can explain half of the deficiencies JO - Thromb Res VL - 92 UR - https://doi.org/10.1016/S0049-3848(98)00131-5 DO - 10.1016/S0049-3848(98)00131-5 ID - Miyata1998 ER - TY - JOUR AU - Perera, L. AU - Foley, C. AU - Darden, T. A. AU - Stafford, D. AU - Mather, T. AU - Esmon, C. T. AU - Pedersen, L. G. PY - 2000 DA - 2000// TI - Modeling zymogen protein C JO - Biophys J VL - 279 UR - https://doi.org/10.1016/S0006-3495(00)76530-1 DO - 10.1016/S0006-3495(00)76530-1 ID - Perera2000 ER - TY - JOUR AU - Poort, S. R. AU - Rosendaal, F. R. AU - Reitsma, P. H. AU - Bertina, R. M. PY - 1996 DA - 1996// TI - A common genetic variation in the 30-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis JO - Blood VL - 88 ID - Poort1996 ER - TY - JOUR AU - Reitsma, P. H. AU - Poort, S. R. AU - Allaart, C. F. AU - Briët, E. AU - Bertina, R. M. PY - 1991 DA - 1991// TI - The spectrum of genetic defects in a panel of 40 Dutch families with symptomatic protein C deficiency type I: heterogeneity and founder effects JO - Blood VL - 78 ID - Reitsma1991 ER - TY - JOUR AU - Roberts, L. N. AU - Patel, R. K. AU - Arya, R. PY - 2009 DA - 2009// TI - Venous thromboembolism and ethnicity JO - Br J Haematol VL - 146 UR - https://doi.org/10.1111/j.1365-2141.2009.07786.x DO - 10.1111/j.1365-2141.2009.07786.x ID - Roberts2009 ER - TY - JOUR AU - Shen, M. C. AU - Lin, J. S. AU - Tsay, W. PY - 1997 DA - 1997// TI - High prevalence of antithrombin III, protein C and protein S deficiency, but no factor V Leiden mutation in venous thrombophilic Chinese patients in Taiwan JO - Thromb Res VL - 87 UR - https://doi.org/10.1016/S0049-3848(97)00141-2 DO - 10.1016/S0049-3848(97)00141-2 ID - Shen1997 ER - TY - JOUR AU - Soare, A. M. AU - Popa, C. PY - 2010 DA - 2010// TI - Deficiencies of proteins C, S and antithrombin and factor V Leiden and the risk of ischemic strokes JO - J Med Life VL - 3 ID - Soare2010 ER - TY - JOUR AU - Souto, J. C. AU - Almasy, L. AU - Borrell, M. AU - Blanco-Vaca, F. AU - Mateo, J. AU - Soria, J. M. AU - Coll, I. AU - Felices, R. AU - Stone, W. AU - Fontcuberta, J. AU - Blangero, J. PY - 2000 DA - 2000// TI - Genetic susceptibility to thrombosis and its relationship to physiological risk factors: the GAIT study. Genetic analysis of idiopathic thrombophilia JO - Am J Hum Genet VL - 67 UR - https://doi.org/10.1086/316903 DO - 10.1086/316903 ID - Souto2000 ER - TY - JOUR AU - Suehisa, E. AU - Nomura, T. AU - Kawasaki, T. AU - Kanakura, Y. PY - 2001 DA - 2001// TI - Frequency of natural coagulation inhibitor (antithrombin III, protein C and protein S) deficiencies in Japanese patients with spontaneous deep vein thrombosis JO - Blood Coagul Fibrinolysis VL - 12 UR - https://doi.org/10.1097/00001721-200103000-00002 DO - 10.1097/00001721-200103000-00002 ID - Suehisa2001 ER - TY - JOUR AU - Tang, L. AU - Guo, T. AU - Yang, R. AU - Mei, H. AU - Wang, H. AU - Lu, X. AU - Yu, J. AU - Wang, Q. AU - Hu, Y. PY - 2012 DA - 2012// TI - Genetic background analysis of protein C deficiency demonstrates a recurrent mutation associated with venous thrombosis in Chinese population JO - PLoS One VL - 7 UR - https://doi.org/10.1371/journal.pone.0035773 DO - 10.1371/journal.pone.0035773 ID - Tang2012 ER - TY - JOUR AU - Tang, L. AU - Lu, X. AU - Yu, J. M. AU - Wang, Q. Y. AU - Yang, R. AU - Guo, T. AU - Mei, H. AU - Hu, Y. PY - 2012 DA - 2012// TI - PROC c.574_576del polymorphism: a common genetic risk factor for venous thrombosis in the Chinese population JO - J Thromb Haemost VL - 10 UR - https://doi.org/10.1111/j.1538-7836.2012.04862.x DO - 10.1111/j.1538-7836.2012.04862.x ID - Tang2012 ER - TY - JOUR AU - Tang, L. AU - Wang, H. F. AU - Lu, X. AU - Jian, X. R. AU - Jin, B. AU - Zheng, H. AU - Li, Y. Q. AU - Wang, Q. Y. AU - Wu, T. C. AU - Guo, H. AU - Liu, H. AU - Guo, T. AU - Yu, J. M. AU - Yang, R. AU - Yang, Y. AU - Hu, Y. PY - 2013 DA - 2013// TI - Common genetic risk factors for venous thrombosis in the Chinese population JO - Am J Hum Genet VL - 92 UR - https://doi.org/10.1016/j.ajhg.2012.12.013 DO - 10.1016/j.ajhg.2012.12.013 ID - Tang2013 ER - TY - JOUR AU - Thomas, R. K. AU - Baker, A. C. AU - Debiasi, R. M. PY - 2007 DA - 2007// TI - High-throughput oncogene mutation profiling in human cancer JO - Nat Genet VL - 39 UR - https://doi.org/10.1038/ng1975 DO - 10.1038/ng1975 ID - Thomas2007 ER - TY - JOUR AU - Torbicki, A. AU - Perrier, A. AU - Konstantinides, S. AU - Agnelli, G. AU - Galiè, N. AU - Pruszczyk, P. AU - Bengel, F. AU - Brady, A. J. AU - Ferreira, D. AU - Janssens, U. AU - Klepetko, W. AU - Mayer, E. AU - Remy-Jardin, M. AU - Bassand, J. P. PY - 2008 DA - 2008// TI - Guidelines on the diagnosis and management of acute pulmonary embolism: the Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC) JO - Eur Heart J VL - 29 UR - https://doi.org/10.1093/eurheartj/ehn475 DO - 10.1093/eurheartj/ehn475 ID - Torbicki2008 ER - TY - JOUR AU - Wildhagen, K. AU - Lutgens, E. AU - Loubele, S. AU - Cate, H. AU - Nicolaes, G. A. F. PY - 2011 DA - 2011// TI - The structure-function relationship of activated protein C: lessons from natural and engineered mutations JO - Thromb Haemost VL - 106 UR - https://doi.org/10.1160/TH11-08-0522 DO - 10.1160/TH11-08-0522 ID - Wildhagen2011 ER - TY - JOUR AU - Zakai, N. A. AU - McClure, L. A. PY - 2011 DA - 2011// TI - Racial differences in venous thromboembolism JO - J Thromb Haemost VL - 9 UR - https://doi.org/10.1111/j.1538-7836.2011.04443.x DO - 10.1111/j.1538-7836.2011.04443.x ID - Zakai2011 ER -